talus osteochondral lesions- talus osteochondritis dissecans. Osteochondritis dissecans of ankle and joints of foot
Conditions
Interventions
Intervention 1: Intervention group: intra-articular injection of vascular stromal cells taken from fat, necessary equipment, svf extraction kit-syringe, SVF preparation: about 100 mL of adipose tissue
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: The symptoms have been continuous for at least 3 months and have not responded to conservative treatment age 18-70 years Patients with grade I, II Bernadet and Harry classification lesions CT SCAN and MRI confirm the diagnosis and no other pathology is involved The patient has the ability to understand the explanations and registers her verbal and written wishes in the informed consent form
Exclusion criteria
Exclusion criteria: presence of inflammatory arthritis such as rheumatoid arthritis, other systemic diseases such as diabetes and systemic inflammatory diseases; Systemic infection History of cardiovascular disease such as previous stroke or heart failure or coagulation problem such as disturbed PT, PTT, INR Any surgery or intra-articular injection Drug users or alcoholics Pregnancy or breastfeeding Severe weight loss in such a way that liposuction is not possible. Abdominal hernia The presence of loose bodies, osteoarthritic changes, impingement spurs, or other pathology
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diameter of Lesion. Timepoint: before entering the study - six months later. Method of measurement: CT scan. | — |
Secondary
| Measure | Time frame |
|---|---|
| Function of ankle. Timepoint: before entering the study - one month later - three months later - six months later. Method of measurement: American Orthopedic Foot and Ankle Society questionnaire.;Pain. Timepoint: before entering the study - one month later - three months later - six months later. Method of measurement: visual analog scale.;Osteoarthritis changes. Timepoint: before entering the study - one month later - three months later - six months later. Method of measurement: Ankle osteoarthritis scale questionnaire.;Lesion grade. Timepoint: before entering the study - six months later. Method of measurement: CT scan - Berndet and harty classification. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSina Hajiaghajani
Shahid Beheshti University of Medical Sciences
Outcome results
None listed