repeated implantation failure (RIF) patients. Complications of attempted introduction of fertilized ovum following in vitro fertilization
Conditions
Interventions
Intervention 1: Intervention group: Group A will include 40 patients who will receive tacrolimus at a dose of 3 mg/daily. The initiation of tacrolimus in this group will begin two days before the tran
Sponsors
Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
No minimum to 39 Years
Inclusion criteria
Inclusion criteria: The patient should be = 39 years old. The patient should have = 3 failures in the IVF. Th1/Th2 cell ratio should be greater than or equal to 10.3.
Exclusion criteria
Exclusion criteria: Patients with abnormal karyotypes, uterine abnormalities or defects, infections, endocrine diseases, and coagulation abnormalities or thrombosis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical pregnancy onset. Timepoint: 14 days after the transfer of the embryo to the uterus. Method of measurement: Positive result of B-hcg test for patients. | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of changes in T-cell helper1/T-cell helper2 (Th1/Th2) ratio between groups. Timepoint: 14 days after the transfer of the embryo to the uterus. Method of measurement: Flow cytometry technique.;Measuring the expression of interleukin-10 (IL-10) between groups. Timepoint: 14 days after the transfer of the embryo to the uterus. Method of measurement: Real-time PCR.;Measuring the expression of interleukin-17 (IL-17) between groups. Timepoint: 14 days after the transfer of the embryo to the uterus. Method of measurement: Real-time PCR. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSaeid Taghiloo
Mazandaran University of Medical Sciences
Outcome results
None listed