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evaluation of Probiotic lozenges, fluoride Mouthwash and Xylitol gum on Streptococcus mutans

Comparative evaluation of Probiotic lozenges tablets with Mouthwash containing fluoride and cetyl pyridinium chloride and chewing gum containing Xylitol on oral Streptococcus mutans coloni

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20231127060200N1
Enrollment
72
Registered
2024-03-04
Start date
2024-04-02
Completion date
Unknown
Last updated
2024-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental caries.

Interventions

Intervention 1: The first intervention group: they will receive one lactogam lozenge daily (a product of Lactogam Company (Tehran-Iran)) immediately after brushing their teeth, and they will be asked

Sponsors

Rafsanjan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 30 Years

Inclusion criteria

Inclusion criteria: Proper oral hygiene (brush at least twice a day) The presence of at least 6 healthy teeth in each jaw without caries or complex restorations and crowns

Exclusion criteria

Exclusion criteria: Suffering from any systemic disease Use of any type of antibiotic and probiotic products during the last month Fluoride therapy and use of fluoride or antibacterial mouthwash during the last two weeks Using birth control pills and being pregnant Use of orthodontic devices and brackets, fixed and mobile prosthesis Presence of sensitivity to probiotic products or other elements in the study such as fluoride or xylitol Suffering from rapidly progressive caries, acute periodontal and gum diseases. smoking

Design outcomes

Primary

MeasureTime frame
The average number of Streptococcus mutans colonies. Timepoint: Sampling of patients will be done before the intervention and also on the 2nd, 14th and 30th days after the intervention. Method of measurement: Sampling of saliva by non-stimulating method and culture.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Nabavizade

Rafsanjan University of Medical Sciences

alinabavizadeh@gmail.com+98 34 3428 0031

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026