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Post-surgical analgesic efficacy of mgso4 versus lignocaine with acetaminophen in asthmatic patients

Post-surgical analgesic efficacy of mgso4 versus lignocaine with acetaminophen in asthmatic patients

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20231124060161N2
Enrollment
70
Registered
2024-05-04
Start date
2023-02-20
Completion date
Unknown
Last updated
2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pain. Pain, unspecified

Interventions

Intervention 1: Intervention group 1: Patients in the intervention Group received intravenous MgSO4 at 50 mg/kg diluted in 100 ml of normal saline over 15 minutes with intravenous acetaminophen 15 m

Sponsors

CMH Rawalpindi
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: all ASA-I and II patients diagnosed with asthma by spirometry pre- and post-bronchodilator therapy with confirmation of reversibility presenting to the surgical department for elective laparoscopic cholecystectomy compliant and optimized on treatment.

Exclusion criteria

Exclusion criteria: major cardiac or respiratory disease low ejection fraction unoptimized for hypertension or diabetes patients with cholecystitis, patients allergic to acetaminophen, MgSO4, lignocaine or nalbuphine patient with a history of asthma exacerbation requiring admission in the last 8 weeks. patients on oral or intravenous steroids for asthma patients unwilling to be included in the study.

Design outcomes

Primary

MeasureTime frame
Analgesia. Timepoint: 24hrs after first analgesics dose. Method of measurement: Visual Analogue Scale (VAS).

Secondary

MeasureTime frame
Hypotension. Timepoint: 1,3,6 hours. Method of measurement: cardiac monitor, sphygmomanometer.;Respiratory depression. Timepoint: 1,3,6 hours. Method of measurement: pulse oximetry, cardiac monitor.;Nausea. Timepoint: 1,3,6 hours. Method of measurement: Visual assessment and patient complaints.;Vomiting. Timepoint: 1,3,6 hours. Method of measurement: Clinical assessment, patient complaints.

Countries

Pakistan

Contacts

Public ContactSaddam Hussain

CMH Rawalpindi

saddam133@yahoo.com+92 344 9017071

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026