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The effect of Propolis supplementation on male infertility

Evaluation of the effects of Propolis Supplementation on Semen Parameters, Oxidative Stress Biomarkers, Sperm DNA Fragmentation and the Expression of Long Non-Coding RNA HOTAIR in Infertile Men with Asthenozoospermia

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20231123060155N1
Enrollment
60
Registered
2024-07-06
Start date
2024-06-21
Completion date
Unknown
Last updated
2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Asthenozoospermia. male infertility

Interventions

Intervention 1: Intervention group: the supplement group will consume three 500 mg capsules containing propolis on the day after each meal for 12 weeks from Shahdineh Golha Co., Isfahan. Intervention

Sponsors

Ahvaz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
20 Years to 50 Years

Inclusion criteria

Inclusion criteria: Willingness to participate in the study At least one year passed since the decision to have children and not using contraceptives Age 20 to 50 years suffering from asthenozoospermia with total sperm motility less than 40% in the semen sample of unknown origin (idiopathic) according to the criteria of the World Health Organization.

Exclusion criteria

Exclusion criteria: The presence of a known cause of infertility (hormonal disorders, epididymal duct obstruction and epididymovarcitis (inflammation of the testicles and epididymis) Drug abuse Alcohol use Having a chronic disease (diabetes, kidney disease, chronic liver disease) Varicocele Infectious diseases characterized by fever and leukocytosis. body mass index (BMI) higher than 30 and less than 18.5 kg/m2

Design outcomes

Primary

MeasureTime frame
Sperm motility. Timepoint: before the start of the intervention and after 3 months of the intervention. Method of measurement: Spermatogram.

Secondary

MeasureTime frame
Oxidative stress. Timepoint: before the start of the intervention and after 3 months of the intervention. Method of measurement: ELISA method.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Majid Karandish

Ahvaz University of Medical Sciences

MKARANDISH@AJUMS.AC.IR+98 916 618 1688

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026