Comparison study of effect of ceftriaxone versus ciprofloxacin treatment on dysentery in children

Evaluating and comparison study of effect of ceftriaxone versus ciprofloxacin treatment on dysentery in children referred to Taleghani Children's Hospital in Gorgan

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20231119060110N1

Enrollment

196

Registered

2024-04-10

Start date

2023-12-01

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute hemorrhagic gastroenteritis. Infectious gastroenteritis and colitis, unspecified

Interventions

Intervention 1: Intervention group: treated with intravenous ceftriaxone treated with intravenous ceftriaxone at a dose of 50 mg/kg daily until the third day. Intervention 2: Intervention group: treat

Eligibility

Sex/Gender

All

Age

2 Years to 15 Years

Inclusion criteria

Inclusion criteria: Not receiving antibiotics during the last week Consent to participate in the study Sensitivity to both ceftriaxone and ciprofloxacin in the initial antibiogram

Exclusion criteria

Exclusion criteria: Any sensitivity to fluoroquinolones and cephalosporins Immune deficiency disease and malnutrition in children No follow up and Low drug compliance of the patient in the 5-day period of treatment

Design outcomes

Primary

Measure	Time frame
Acute bloody diarrhea frequency and severity. Timepoint: 3 days and 5 days after the start of treatment. Method of measurement: By asking the patient and parents.	—

Secondary

Measure	Time frame
Cease of fever. Timepoint: Before the start of the intervention, the 3rd and 5th day of the study. Method of measurement: By checking vital signs and stool culture.;Stool cultures becoming negative on the 3rd day of starting treatment. Timepoint: Before the start of the intervention, the 3rd and 5th day of the study. Method of measurement: By checking vital signs and stool culture.;Duration of symptom reduction (reduction of diarrhea frequency). Timepoint: Before the start of the intervention, the 3rd and 5th day of the study. Method of measurement: By checking vital signs and stool culture.;Duration of symptom reduction( reduction of blood and mucus in stool ). Timepoint: Before the start of the intervention, the 3rd and 5th day of the study. Method of measurement: By checking vital signs and stool culture.;Duration of symptom reduction( recovery in general condition). Timepoint: Before the start of the intervention, the 3rd and 5th day of the study. Method of measurement: By checking vital signs and stool culture.	—

Measure

Time frame

Cease of fever. Timepoint: Before the start of the intervention, the 3rd and 5th day of the study. Method of measurement: By checking vital signs and stool culture.;Stool cultures becoming negative on the 3rd day of starting treatment. Timepoint: Before the start of the intervention, the 3rd and 5th day of the study. Method of measurement: By checking vital signs and stool culture.;Duration of symptom reduction (reduction of diarrhea frequency). Timepoint: Before the start of the intervention, the 3rd and 5th day of the study. Method of measurement: By checking vital signs and stool culture.;Duration of symptom reduction( reduction of blood and mucus in stool ). Timepoint: Before the start of the intervention, the 3rd and 5th day of the study. Method of measurement: By checking vital signs and stool culture.;Duration of symptom reduction( recovery in general condition). Timepoint: Before the start of the intervention, the 3rd and 5th day of the study. Method of measurement: By checking vital signs and stool culture.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactShafighe Taneh

Gorgan University of Medical Sciences

shafighetaneh@gmail.com+98 17 3222 7720

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026