The effect of pineapple gel on palatal wound healing after gingival graft

Investigating The Effect Of Bromelain Gel Added To Periodontal Pack Compared To Periodontal Pack Alone On The Healing Of Palatal Wound Resulting From Harvesting The Free Gingival Graft On Patients With Keratinized Gingival Width Deficiency Who Are Candidates For Gingival Grafting; A Parallel Clinical Trial Study

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20231118060098N1

Enrollment

Registered

2024-01-12

Start date

2024-03-10

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Palate wound.

Interventions

Intervention 1: Intervention group: In this study free gingival graft surgery is performed by removing the graft from the palate area, 1% bromelain gel, a polymer gel made from mixing biocompatible po

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients over 18 years old The need for free gingival graft around the tooth or implant Systemically healthy Non-smokers Graft dimensions 10 mm wide and 15 to 20 mm long

Exclusion criteria

Exclusion criteria: Active gag reflex Presence of periodontal disease Lack of sensation Mobility and occlusal trauma Missing canine teeth up to maxillary first molar Additional forces including mechanical forces from orthodontics and traumatic occlusion Systemic diseases that are contraindications for periodontal surgeries or have interactions by tissue repair Pregnancy and breastfeeding

Design outcomes

Primary

Measure	Time frame
The average area of the remaining wound in the palate. Timepoint: Days 7, 14, 21 and 28 after surgery. Method of measurement: Image J computer program to check the area of the remaining wound.;The amount of bleeding after surgery. Timepoint: The first 3 days after surgery. Method of measurement: Questionnaire and observation.;The degree of color matching. Timepoint: Days 7, 14, 21 and 28 after surgery. Method of measurement: Adobe Photoshop CS3 computer program to check Brightness parameters.;The amount of epithelialization. Timepoint: Days 7, 14, 21 and 28 after surgery. Method of measurement: Using 3% H2O2 and observing oxygen bubbles.;Average index of pain and discomfort. Timepoint: Days 7, 14, 21 and 28 after surgery. Method of measurement: Questionnaire and VAS chart.;Lundry's healing index next. Timepoint: Days 7, 14, 21 and 28 after surgery. Method of measurement: Direct touch and examination by a specialist.	—

Measure

Time frame

The average area of the remaining wound in the palate. Timepoint: Days 7, 14, 21 and 28 after surgery. Method of measurement: Image J computer program to check the area of the remaining wound.;The amount of bleeding after surgery. Timepoint: The first 3 days after surgery. Method of measurement: Questionnaire and observation.;The degree of color matching. Timepoint: Days 7, 14, 21 and 28 after surgery. Method of measurement: Adobe Photoshop CS3 computer program to check Brightness parameters.;The amount of epithelialization. Timepoint: Days 7, 14, 21 and 28 after surgery. Method of measurement: Using 3% H2O2 and observing oxygen bubbles.;Average index of pain and discomfort. Timepoint: Days 7, 14, 21 and 28 after surgery. Method of measurement: Questionnaire and VAS chart.;Lundry's healing index next. Timepoint: Days 7, 14, 21 and 28 after surgery. Method of measurement: Direct touch and examination by a specialist.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFateme Godarzi Moghadam

Tehran University of Medical Sciences

fateme.godarzii1998@gmail.com+98 21 4279 4000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026