Heart failure. Heart failure
Conditions
Interventions
Intervention 1: Intervention group: Recipient of allopurinol tablets 100 mg daily for six months. Intervention 2: Control group: Recipient of daily multivitamin tablets for six months.
Sponsors
Hamedan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
30 Years to 75 Years
Inclusion criteria
Inclusion criteria: Heart failure patients with ejection fraction <50% according to echocardiography Desire to cooperate and participate in research
Exclusion criteria
Exclusion criteria: Dissatisfaction to continue cooperation in the research project Taking drugs that interfere with allopurinol by the patient Increase in blood creatinine following allopurinol intake during research Occurrence of any complications following the use of allopurinol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood uric acid level. Timepoint: At the beginning of the study and six months later. Method of measurement: Blood test. | — |
Secondary
| Measure | Time frame |
|---|---|
| Ejection fraction. Timepoint: At the beginning of the study and six months later. Method of measurement: Echocardiography.;Peripheral edema. Timepoint: At the beginning of the study and six months later. Method of measurement: Physical exam.;Orthopnea. Timepoint: At the beginning of the study and six months later. Method of measurement: Taking history.;Paroxysmal nocturnal dyspnea. Timepoint: At the beginning of the study and six months later. Method of measurement: Taking history.;Dyspnea. Timepoint: At the beginning of the study and six months later. Method of measurement: Taking history. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMehran Behnam
Hamedan University of Medical Sciences
Outcome results
None listed