Intravenous Desmopressin, Tranexamic Acid, and Their Combined Impact on Intra-Operative Bleeding in Functional Endoscopic Sinus Surgery

Evaluation of the effect of Intravenous Desmopressin, Tranexamic Acid, and their combination on intra-operative bleeding during functional endoscopic sinus surgery of adults

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20231112060028N1

Enrollment

Registered

2023-11-15

Start date

2023-11-12

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Chronic sinusitis. Condition 2: Nasal polyp. Chronic sinusitis Nasal polyp

Interventions

Intervention 1: Intervention group (Desmopressin Group): Patients will undergo general anesthesia and FESS as indicated under the routine standard of care. Patients in the DDAVP group will receive 0.3

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: First-time candidates of bilateral FESS due to chronic rhinosinusitis with polyp Patients should have a normal test result (CBC, PT, PTT, renal function tests, electrolytes) Patients classified as American Society of Anesthesiologists (ASA) I and ASA II

Exclusion criteria

Exclusion criteria: Wegener's disease Sarcoidosis Sinonasal malignancy Bleeding disorders Known hypersensitivity to TXA or DDAVP Active venous or arterial thromboembolic disease History of seizures Renal impairment (defined as a creatinine clearance below 50 mL/min) Disseminated Intravascular Coagulation (DIC) or any coagulopathy Color vision disorders Pregnancy and breastfeeding Heart failure or other conditions needing fluid restrictions Hyponatremia or history of hyponatremia Revision surgeries Poorly controlled hypertension or cerebrovascular disease History of significant coronary artery disease or arrhythmias

Design outcomes

Primary

Measure	Time frame
Intra-operative blood loss. Timepoint: Intra-operative and at the end of the operation. Method of measurement: The volume of blood suctioned during the operation excluding the normal volume of saline used.;Surgical field bleeding score. Timepoint: Intraoperative. Method of measurement: BOEZAART grading scale for scoring surgical field bleeding.	—

Secondary

Measure	Time frame
Duration of surgery. Timepoint: At the end of the operation. Method of measurement: The end of the operation minus the start of the operation.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Faramarzi

Shiraz University of Medical Sciences

ali_faramarzi@sums.ac.ir+98 71 3629 1417

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026