Schizophrenia. Schizophrenia
Conditions
Interventions
Intervention 1: Intervention group: According to previous studies, the dose of vitamin D supplement is 50,000 IU weekly for 12 weeks, and after 12 weeks (three months from the start of taking the supp
Sponsors
Yazd University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Diagnosis of chronic outpatient schizophrenia (at least three years have passed since the onset of the disease and at least one year under treatment with antipsychotic drugs) based on DSM5 by a psychiatrist Vitamin D level below 30ng under treatment for at least 8 weeks with a fixed dose of the drug score question (PANSS) above 70
Exclusion criteria
Exclusion criteria: Received ECT in the past two months Mental retardation Organic brain disease and history of head trauma History of drug and alcohol use Non-cooperation in filling out the questionnaire Non-cooperation in taking medicine or changing its dosage? Non-cooperation in taking vitamin D supplements Kidney, heart, thyroid disorders and diseases, hemorrhagic diseases and malignancies Pregnancy and breastfeeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Mocha cognitive test MoCA. Timepoint: The beginning of the study, the end of week 12, the end of week 24. Method of measurement: Moka cognitive assessment questionnaire is measured and implemented for all participants by a clinical psychologist.?.;PANSS positive and negative symptom evaluation test. Timepoint: The beginning of the study, the end of week 12, the end of week 24. Method of measurement: The questionnaire for evaluating positive and negative symptoms of schizophrenia is measured and implemented by a clinical psychologist for all participants.;Vitamin D serum level. Timepoint: The beginning of the study, the end of week 12, the end of week 24. Method of measurement: In order to perform laboratory tests before and after the intervention, 10 cc of venous blood will be collected, its serum will be separated and removed. All tests are performed in a single laboratory in a public hospital. Prescribing the test and interpretation of the results will be done by the psychiatrist of Yazd Psychiatric Hospital. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMalihe Samsami
Yazd University of Medical Sciences
Outcome results
None listed