Effect of intravenous and topical lidocaine in endoscopy

Evaluation of the effect of intravenous lidocaine compared to topical lidocaine in patients who are candidates for esophagogastroduodenoscopy

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20231107059983N1

Enrollment

Registered

2024-04-25

Start date

2024-04-19

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients who are candidates for esophagogastroduodenoscopy. Patients who are candidates for esophagogastroduodenoscopy

Interventions

Intervention 1: The first Intervention group: The first group received topical lidocaine in the form of 4 puffs of lidocaine spray10% five minutes before the start of sedation, then 1 mg/kg of propofo

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 18 to 65 year-old patients candidate for Esophagogastroduodenoscopy ASA class I or II

Exclusion criteria

Exclusion criteria: Age65y/o ASA class III or more Sensitivity to lidocaine Emergent patients Patient dissatisfaction

Design outcomes

Primary

Measure	Time frame
1- Investigating the amount of prescribed propofol in maintenance doses in patients receiving intravenous lidocaine compared to topical lidocaine 2- Investigating the amount of blood pressure changes in patients receiving intravenous lidocaine compared to topical lidocaine 3- Investigating the amount of heart rate changes in patients receiving Intravenous lidocaine compared to topical lidocaine 4- Investigating the amount of changes in oxygen saturation in patients receiving intravenous lidocaine compared to topical lidocaine 5- Investigating the occurrence of gag reflex in patients receiving intravenous lidocaine compared to topical lidocaine 6- Examining the rate of organ movement in patients receiving intravenous lidocaine compared to topical lidocaine 7- Examining the incidence of nausea in patients receiving intravenous lidocaine compared to topical lidocaine 8- Examining the incidence of vomiting in patients receiving lidocaine Intravenous compared to topical lidocaine 9- Investigating the incidence of sore throat in patients receiving intravenous lidocaine compared to topical lidocaine 10- Investigating the time of discharge from recovery in patients receiving intravenous lidocaine compared to topical lidocaine 11- Investigating the level of endoscopist satisfaction with esophagogastroduodenoscopy Patients receiving intravenous lidocaine compared with topical lidocaine. Timepoint: Changes in blood pressure, heart rate, and blood oxygen saturation are constantly monitored and recorded during the process. The incidence of gag reflex and the amount of organ movement during esophagogastroduodenoscopy are measured and recorded. The movement of the limbs means lifting the head, raising the hands towards the entrance of the endoscope probe, or trying to sit or stand up. The duration of recovery, which is the time interval between the completion of endoscopy and the Aldrete score reaching a score of more than 8, is checked in each patient. The presence of nausea and	—

Measure

Time frame

1- Investigating the amount of prescribed propofol in maintenance doses in patients receiving intravenous lidocaine compared to topical lidocaine 2- Investigating the amount of blood pressure changes in patients receiving intravenous lidocaine compared to topical lidocaine 3- Investigating the amount of heart rate changes in patients receiving Intravenous lidocaine compared to topical lidocaine 4- Investigating the amount of changes in oxygen saturation in patients receiving intravenous lidocaine compared to topical lidocaine 5- Investigating the occurrence of gag reflex in patients receiving intravenous lidocaine compared to topical lidocaine 6- Examining the rate of organ movement in patients receiving intravenous lidocaine compared to topical lidocaine 7- Examining the incidence of nausea in patients receiving intravenous lidocaine compared to topical lidocaine 8- Examining the incidence of vomiting in patients receiving lidocaine Intravenous compared to topical lidocaine 9- Investigating the incidence of sore throat in patients receiving intravenous lidocaine compared to topical lidocaine 10- Investigating the time of discharge from recovery in patients receiving intravenous lidocaine compared to topical lidocaine 11- Investigating the level of endoscopist satisfaction with esophagogastroduodenoscopy Patients receiving intravenous lidocaine compared with topical lidocaine. Timepoint: Changes in blood pressure, heart rate, and blood oxygen saturation are constantly monitored and recorded during the process. The incidence of gag reflex and the amount of organ movement during esophagogastroduodenoscopy are measured and recorded. The movement of the limbs means lifting the head, raising the hands towards the entrance of the endoscope probe, or trying to sit or stand up. The duration of recovery, which is the time interval between the completion of endoscopy and the Aldrete score reaching a score of more than 8, is checked in each patient. The presence of nausea and

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNiloofar Hosseini

Bandare-abbas University of Medical Sciences

niloofar.hosseini22@gmail.com+98 76 3333 3280

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026