Patients should be intubated and under mechanical ventilation.. Dependence on respirator [ventilator] status
Conditions
Interventions
Intervention 1: Intervention group: Endotracheal suction with N-acetylcysteine is such that 2 ml of 20% N-acetyl cysteine liquid solution is poured by the researcher into the patient s tracheal tube d
Sponsors
Zabol University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: Patients who are connected to mechanical ventilation for at least 48 hours and at most one week Patients with endotracheal tubes Patients who are between 20 and 60 years old Patients who are hemodynamically stable (heart rate between 60-100 beats per minute, blood pressure between 160/100-110/60 mmHg, Spo2 more than 90%, urinary output more than 30 ml/hour) Patients with normal electrolyte levels and no cardiac arrhythmia Insensitivity to N-acetylcysteine and other drugs Absence of pulmonary edema, chronic obstructive pulmonary diseases and asthma Patients who do not have chest trauma or chest tube Absence of brain edema, spinal cord injury, increased intracranial pressure
Exclusion criteria
Exclusion criteria: Patients who are hemodynamically unstable (heart rate less than 60 beats per minute, blood pressure less than 100/60 mmHg, Spo2 less than 90%) Any changes in mechanical ventilation settings during the study Death of the patient Lack of consent of the patient's family Use of muscle relaxants and inotropic drugs during the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Arterial oxygen saturation, which is considered as a hemodynamic parameter. Timepoint: The Arterial oxygen saturation is measured at the beginning of the study (before the intervention) and 1, 5 and 30 minutes after the intervention. Method of measurement: It is controlled and recorded by means of monitoring connected to the patient.;Respiratory rate, which is considered as a hemodynamic parameter. Timepoint: The Respiratory rate is measured at the beginning of the study (before the intervention) and 1, 5 and 30 minutes after the intervention. Method of measurement: For 1 minute, the Respiratory rate is counted and recorded in the patient's chest by observation method.;Arterial blood gases include PH, PCO2, PO2, HCO3, SPO2. Timepoint: Arterial blood gases are measured at the beginning of the study (5 minutes before the intervention) and 25 minutes after the intervention. Method of measurement: Blood gas Technomedica Arterial Blood Gas Analyzer Gastat-720 series.;Heart rate, which is considered as a hemodynamic parameter. Timepoint: The heart rate is measured at the beginning of the study (before the intervention) and 1, 5 and 30 minutes after the intervention. Method of measurement: It is controlled and recorded by means of monitoring connected to the patient.;Blood pressure, which is considered as a hemodynamic parameter. Timepoint: The blood pressure is measured at the beginning of the study (before the intervention) and 1, 5 and 30 minutes after the intervention. Method of measurement: It is controlled and recorded by means of monitoring connected to the patient. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAhmad Absalan
Zabol University of Medical Sciences
Outcome results
None listed