Comparing the effectiveness of Ciprofloxacin, Ceftriaxone, and Gentamicin for preventing bacteriuria after transurethral lithotripsy (TUL)

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20231031059918N1

Enrollment

264

Registered

2023-11-13

Start date

2023-11-25

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Comparing the effectiveness of ciprofloxacin, ceftriaxone, and gentamicin for preventing bacteriuria after transurethral lithotripsy.

Interventions

Intervention 1: Intervention group: 88 patients use 1 g ceftriaxone 30 minutes before surgery. Intervention 2: Intervention group: 88 patients are injected with 400mg ciprofloxacin 30 minutes before s

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients with middle and distal ureteral calculi with negetive urine culture that are going to undergo TUL (the maximum diameter of the stone is <2 cm) Age 18 to 65 years old.

Exclusion criteria

Exclusion criteria: Asymptomatic patients with colony count = 10 5 CFU/mL or a symptomatic UTI with colony count = 10 3 CFU/mL Patients with any catheter. Patients with preoperative fever (body temperature = 38°C) Patients with a history of diabetes. Patients with immunocompromised diseases or using immunosuppressive drugs Patients with abnormal renal function Patients who have received antimicrobial treatment within two weeks before enrollment Pregnant or breastfeeding women Patients who are allergic to our research drugs.

Design outcomes

Primary

Measure	Time frame
Significant bacteriuria was defined asymptomatic patients with colony count = 10 5 CFU/mL or a symptomatic UTI with colony count = 10 3 CFU/mL. Timepoint: After 48 hour of surgery, routine urine tests and urine bacterial cultures, will be recorded. Method of measurement: Routine urine tests and urine bacteria culture are done in the Rahnemoun hospital laboratory.;Febrile urinary tract infection (fUTI) is defined as a body temperature of 38.5 C accompanying urinary tract infection after surgery. Timepoint: After 48 hour of surgery. Method of measurement: body temperature by thermometer will be recorded.;•SIRS criteria defined by: WBC 12000 , heart rate > 90 per minute , temperature 38 C , respiratory rate >20 or pCO2 < 32 . (Presence of two or more of these criteria is accepted as SIRS.). Timepoint: After 48 hour of surgery. Method of measurement: Routine urine tests and urine bacteria culture are done in the Rahnemoun hospital laboratory.	—

Measure

Time frame

Significant bacteriuria was defined asymptomatic patients with colony count = 10 5 CFU/mL or a symptomatic UTI with colony count = 10 3 CFU/mL. Timepoint: After 48 hour of surgery, routine urine tests and urine bacterial cultures, will be recorded. Method of measurement: Routine urine tests and urine bacteria culture are done in the Rahnemoun hospital laboratory.;Febrile urinary tract infection (fUTI) is defined as a body temperature of 38.5 C accompanying urinary tract infection after surgery. Timepoint: After 48 hour of surgery. Method of measurement: body temperature by thermometer will be recorded.;•SIRS criteria defined by: WBC 12000 , heart rate > 90 per minute , temperature 38 C , respiratory rate >20 or pCO2 < 32 . (Presence of two or more of these criteria is accepted as SIRS.). Timepoint: After 48 hour of surgery. Method of measurement: Routine urine tests and urine bacteria culture are done in the Rahnemoun hospital laboratory.

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Countries

Iran (Islamic Republic of)

Contacts

Public Contactnazanin Akhavan

Yazd University of Medical Sciences

nazanin1379akhavan@gmail.com+98 35 3523 6600

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026