Comparing the effect of "inference-based therapy and treatment with selective serotonin reuptake inhibitors" to "selective serotonin reuptake inhibitors" on obsessive-compulsive disorder

The Effectiveness of Inference-based Therapy Combined with Pharmacotherapy with Selective Serotonin Reuptake Inhibitors Compared to Selective Serotonin Reuptake Inhibitors Monotherapy in Treating Patients with Obsessive-Compulsive Disorder with Good Insight

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20231029059893N1

Enrollment

Registered

2023-11-25

Start date

2023-11-11

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obsessive Compulsive Disorder. Mixed obsessional thoughts and acts

Interventions

Intervention 1: First intervention group: Pharmacotherapy with selective serotonin reuptake inhibitors and inference-based therapy

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: A primary diagnosis of obsessive compulsive disorder with good insight Minimum level of education :High school diploma Age between 18 to 50 Absence of suicidal risk/ current suicidal ideation

Exclusion criteria

Exclusion criteria: current substance abuse comorbid personality disorders, psychotic disorders, an organic mental disorder, a pervasive developmental disorder or mental retardation evidence or diagnosis of bipolar disorder.

Design outcomes

Primary

Measure	Time frame
The patient's score on Yale-Brown Obsessive-Compulsive Scale. Timepoint: Before the start of the intervention and after the end of the intervention. Method of measurement: Yale-Brown Obsessive-Compulsive Scale.	—

Secondary

Measure	Time frame
The patient's score on the World Health Organization Quality of Life questionnaire - brief version. Timepoint: Before the start of the intervention and after the end of the intervention. Method of measurement: World Health Organization Quality of Life questionnaire - brief version.;The patient's score on Beck Depression Inventory. Timepoint: Before the start of the intervention and after the end of the intervention. Method of measurement: Beck Depression Inventory.;The patient's score on Beck Anxiety Inventory. Timepoint: Before the start of the intervention and after the end of the intervention. Method of measurement: Beck Anxiety Inventory.;The patient's score on Inferential Confusion Questionnaire, Extended Version. Timepoint: Before the start of the intervention and after the end of the intervention. Method of measurement: Inferential Confusion Questionnaire, Extended Version.	—

Measure

Time frame

The patient's score on the World Health Organization Quality of Life questionnaire - brief version. Timepoint: Before the start of the intervention and after the end of the intervention. Method of measurement: World Health Organization Quality of Life questionnaire - brief version.;The patient's score on Beck Depression Inventory. Timepoint: Before the start of the intervention and after the end of the intervention. Method of measurement: Beck Depression Inventory.;The patient's score on Beck Anxiety Inventory. Timepoint: Before the start of the intervention and after the end of the intervention. Method of measurement: Beck Anxiety Inventory.;The patient's score on Inferential Confusion Questionnaire, Extended Version. Timepoint: Before the start of the intervention and after the end of the intervention. Method of measurement: Inferential Confusion Questionnaire, Extended Version.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSamaneh Karbakhsh Ravari

Shiraz University

samaneh.karbakhsh@hafez.shirazu.ac.ir+98 71 3613 4000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026