Diabetic nephropathy. Type 2 diabetes mellitus with diabetic nephropathy
Conditions
Interventions
Intervention 1: Intervention group: Chicory capsule (containing dried chicory root extract powder) (three times a day, one capsule of 300 mg each, fasting, afternoon and before bedtime) for 12 weeks,
Sponsors
Gorgan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
35 Years to 75 Years
Inclusion criteria
Inclusion criteria: Diabetic patients aged 35 to 75 years Body mass index below 35, Having microalbuminuria (more than 30 mg/day) Consent to participate in the study
Exclusion criteria
Exclusion criteria: History of allergy to herbal medicines contained in the composition, Presence of pregnancy and lactation, Participation in another clinical study in the field of diabetic nephropathy in the 2 months prior to entering the present study, Presence of another kidney disease other than diabetic nephropathy, Thyroid disorders, Patients requiring insulin injections, Consumption of antibiotics or being treated with angiotensin-converting enzyme inhibitor or angiotensin receptor blocker
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement in albuminuria over the 12-week study. Timepoint: At the beginning of the study (before the intervention), 12 weeks after the intervention. Method of measurement: Laboratory tests. | — |
Secondary
| Measure | Time frame |
|---|---|
| Increase in GFR,. Timepoint: Beginning of intervention (before intervention) and 12 weeks after intervention. Method of measurement: CKD-EPI equation for calculating GFR.;Reduce Hb A1C level,. Timepoint: Beginning of intervention (before intervention) and 12 weeks after intervention. Method of measurement: Laboratory tests.;Reduce uric acid,. Timepoint: Beginning of intervention (before intervention) and 12 weeks after intervention. Method of measurement: Laboratory tests.;Reduce creatinine and urea,. Timepoint: Beginning of intervention (before intervention) and 12 weeks after intervention. Method of measurement: Laboratory tests.;Reduce lipid profile (triglyceride, cholesterol, LDL, HDL),. Timepoint: Beginning of intervention (before intervention) and 12 weeks after intervention. Method of measurement: Laboratory tests.;Reduce fasting glucose (FBS),. Timepoint: Beginning of intervention (before intervention) and 12 weeks after intervention. Method of measurement: Laboratory tests.;Reduced liver aminotransferases (AST, ALT). Timepoint: Beginning of intervention (before intervention) and 12 weeks after intervention. Method of measurement: Laboratory tests.;Reduced BMI, WHR. Timepoint: Beginning of intervention (before intervention), after 8 and 12 weeks of study. Method of measurement: Anthropometric measures. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMehdi Zarvandi
Gorgan University of Medical Sciences
Outcome results
None listed