Non-alcoholic fatty liver disease. Fatty (change of) liver, not elsewhere classified Nonalcoholic fatty liver disease [NAFLD]
Conditions
Interventions
Intervention 1: Intervention group: In the intervention group, chicory capsule (containing dried powder of chicory root extract), along with the method of use (one 300 mg capsule three times a day, fa
Sponsors
Gorgan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Age 18 to 60 years, male or female, liver grade 2 or 2 to 3 or 3 diagnosed by ultrasound (US) or diagnosis of NAFLD by fibroscan
Exclusion criteria
Exclusion criteria: history of allergy to herbal medicines in the composition, Presence of pregnancy and breastfeeding History of liver problems, including liver cirrhosis.Hereditary liver diseases, such as Wilson's, hemochromatosis and tumoral and parasitic liver diseases, obesity (BMI>35), diabetes participating in another clinical study of fatty liver in 2 months before entering the present study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main outcome is the improvement of the degree of fatty liver during 8 weeks of study. Timepoint: Measurement of fatty liver degree before the intervention, and 8 weeks after the intervention. Method of measurement: sonography. | — |
Secondary
| Measure | Time frame |
|---|---|
| Decrease in the level of aminotransferases. Timepoint: Before the intervention and 8 weeks after the intervention. Method of measurement: Laboratory test.;Decrease in the level of fat profile. Timepoint: Before the intervention and 8 weeks after the intervention. Method of measurement: Laboratory test.;Decrease in the level of fasting sugar,. Timepoint: Before the intervention and 8 weeks after the intervention. Method of measurement: Laboratory test.;Decrease in the level of ferritin. Timepoint: Before the intervention and 8 weeks after the intervention. Method of measurement: Laboratory test.;Decrease in the level of total bilirubin. Timepoint: Before the intervention and 8 weeks after the intervention. Method of measurement: Laboratory test.;Decrease in the BMI( Body Mass Index). Timepoint: Before the intervention and 8 & 12 weeks after the intervention. Method of measurement: Anthropometric measures.;Decrease in the WHR (Waist to hip). Timepoint: Before the intervention and 8 & 12 weeks after the intervention. Method of measurement: Anthropometric measures. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMehdi Zarvandi
Gorgan University of Medical Sciences
Outcome results
None listed