Ankle Sprain. Sprain of ankle
Conditions
Interventions
Intervention 1: First Intervention group: Platelet-rich plasma (a single injection of 4 cc of liquid containing platelets with 5 to 6 times concentration: 1.5 cc around the ligament and 2.5 cc intra-a
2 cc of 20% dextrose with 2 cc of 2% lidocaine solution: 1.5 cc around the ligament and 2.5 cc intra-articular). Intervention 3: Control group: Normal saline (a single injection of 4 cc of 0.9% normal
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Adult Patients (18 Years and Older). Patient with Complaints of Chronic Ankle Pain (for 12 Weeks or More) due to Lateral Sprain and Chronic Ankle Ligament Damage Who Have Not Responded to Conservative Treatments.
Exclusion criteria
Exclusion criteria: Patients with History of Rheumatologic Disorders. Patients with History of Diabetes Mellitus. Patients with History of Recent Fractures of the Ankle Bones (Within the Last 3 Months). Patients with History of Infection Around the Ankle Joint. Patients with History of Intra-Articular or Extra-Articular Injections in the Ankle Region in the Past Year. Patients with History of Ankle Surgery. Patients who Use Anticoagulant Drugs. Patients who Had Any Previous Allergic Reaction to Dextrose or Lidocaine Injection. Patients with Accompanying Ankle Injury such as Osteochondritis Dissecans of the Talus.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Determination and comparison of pain. Timepoint: Before intervention, 4 and 12 weeks after the intervention. Method of measurement: Visual analogue scale questionnaire.;Determination and comparison of pain. Timepoint: Before intervention, 4 and 12 weeks after the intervention. Method of measurement: American Orthopaedic Foot and Ankle Society (AOFAS) Ankle-Hindfoot questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Determination and comparison of function. Timepoint: Before intervention, 4 and 12 weeks after the intervention. Method of measurement: American Orthopaedic Foot and Ankle Society (AOFAS) Ankle-Hindfoot questionnaire.;Determination and comparison of alignment. Timepoint: Before intervention, 4 and 12 weeks after the intervention. Method of measurement: American Orthopaedic Foot and Ankle Society (AOFAS) Ankle-Hindfoot questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMaryam Cheraghali
Tehran University of Medical Sciences
Outcome results
None listed