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The effect of aromatherapy with lemon essence on nausea, vomiting, pain, and delirium after heart surgery

Investigating the Effect of Inhalation Aromatherapy with Lemon Essence on Nausea, Vomiting, Pain, and Delirium in Patients Undergoing Coronary Artery Bypass Graft Surgery

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20231021059799N2
Enrollment
104
Registered
2025-06-17
Start date
2025-06-22
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Postoperative Delirium. Condition 2: Postoperative Nausea and Vomiting. Condition 3: Postoperative Pain. Delirium due to known physiological condition Other complications of anesthesia Other complications of anesthesia

Interventions

Intervention 1: "Intervention group:" Patients will undergo inhalation aromatherapy with lemon essence. The lemon essence, with 100% purity, is produced by Barij Essence Company, and its quality will

Sponsors

Bagheiat-allah University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 80 Years

Inclusion criteria

Inclusion criteria: Age between 40 and 80 years Scheduled for coronary artery bypass graft surgery. ASA physical status class II and III. Patient is alert and oriented to time, place, and person, and able to speak No participation in other studies involving similar interventions. No history of postoperative delirium No diagnosis of known psychiatric disorders (e.g., severe depression, anxiety, psychosis, etc.) No history of alcohol use or antipsychotic drug consumption

Exclusion criteria

Exclusion criteria: History of allergy related to herbal extracts. Presence of olfactory dysfunction or structural nasal damage. History of reoperation following cardiac surgery. Anticipated prolonged surgery duration beyond standard limits, as assessed by the cardiac surgeon. History of receiving higher-than-usual doses of opioid medications in the cardiac intensive care unit. High risk of severe postoperative bleeding as predicted by the clinical care team.

Design outcomes

Primary

MeasureTime frame
Incidence of delirium within 72 hours after coronary artery bypass graft surgery. Timepoint: Delirium will be assessed the night before surgery (as baseline), immediately after the patient’s transfer to the cardiac intensive care unit, and then daily up to 72 hours following coronary artery bypass graft surgery. Method of measurement: Delirium will be evaluated using the Intensive Care Delirium Screening Checklist by a nurse blinded to the intervention type. This tool consists of 8 items (altered level of consciousness, inattention, disorientation, hallucination-delusion-psychosis, psychomotor agitation or retardation, inappropriate speech or mood, sleep/wake cycle disturbance, and symptom fluctuation) used to diagnose delirium in patients admitted to the intensive care unit.;Severity of pain within 72 hours after coronary artery bypass graft surgery. Timepoint: Pain intensity will be measured the night before surgery (as baseline), immediately after the patient’s transfer to the cardiac intensive care unit, and then at 6, 12, 24, 48, and 72 hours following coronary artery bypass graft surgery. Method of measurement: Pain intensity will be measured using the Numeric Pain Rating Scale. The patient selects a number between zero (no pain) and 10 (worst possible pain) and circles it. Additionally, the location of pain and the amount of opioid consumption will be recorded.;Severity of nausea and vomiting within 72 hours after coronary artery bypass graft surgery. Timepoint: Nausea and vomiting intensity will be measured the night before surgery (as baseline), immediately after the patient’s transfer to the cardiac intensive care unit, and then at 6, 12, 24, 48, and 72 hours following coronary artery bypass graft surgery. Method of measurement: The intensity of nausea and vomiting will be measured using the Numeric Nausea and Vomiting Scale. The patient selects a number between zero (no nausea and vomiting) and 10 (worst possible nausea and vomiting) and circles it.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSiavash Sangi

Bagheiat-allah University of Medical Sciences

siavashsangi@gmail.com+98 21 8804 0060

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026