The effect of prescribing intravenous Ketamine in the anesthesia of patients undergoing coronary artery bypass surgery

The effect of prescribing intravenous ketamine during induction of anesthesia on the incidence of delirium and the time of endotracheal tube removal in patients undergoing coronary artery bypass surgery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20231021059795N1

Enrollment

Registered

2024-04-20

Start date

2024-04-09

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Delirium. Condition 2: Extubation time. Other complications of anesthesia Other complications of anesthesia

Interventions

Intervention 1: Intervention group: Intravenous ketamine with a dose of 0.5mg/kg up to a maximum of 50mg will be administered as an infusion in 100cc of 0.9% normal saline serum in a maximum time of 5

Eligibility

Sex/Gender

All

Age

40 Years to 80 Years

Inclusion criteria

Inclusion criteria: Ages between 40 and 80 years ASA class l, ll lll

Exclusion criteria

Exclusion criteria: Having a history of postoperative delirium The presence of underlying mental illness Taking antipsychotic drugs Having a history of alcohol consumption Presence of cerebrovascular disease Perform valvular surgery BMI > 38 kg/m2 Postoperative stroke Postoperative bleeding Longer operation time than usual Need for re-surgery History of underlying lung disease

Design outcomes

Primary

Measure	Time frame
Incidence rate of delirium after cardiac surgery. Timepoint: In the first 24 hours and the second 24 hours after the operation. Method of measurement: Intensive Care Delirium Screening Checklist (ICDSC).;Extubation time. Timepoint: Up to the first 12 hours of the postoperative period. Method of measurement: Registering patients' extubation time (according to hours: during the first 4 hours after entering the ward, the first 6 hours after entering the ward, the first 8 hours after entering the ward, the first 12 hours after entering the ward).	—

Measure

Time frame

Incidence rate of delirium after cardiac surgery. Timepoint: In the first 24 hours and the second 24 hours after the operation. Method of measurement: Intensive Care Delirium Screening Checklist (ICDSC).;Extubation time. Timepoint: Up to the first 12 hours of the postoperative period. Method of measurement: Registering patients' extubation time (according to hours: during the first 4 hours after entering the ward, the first 6 hours after entering the ward, the first 8 hours after entering the ward, the first 12 hours after entering the ward).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Aligholizadeh

Iran University of Medical Sciences

gholizade001@gmail.com+98 13 4351 2673

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026