The effect of adding the N-acetylcysteine drug to Del Nido's cardioplegia solution on the oxidative stress capacity In patients undergoing coronary artery bypass surgery

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20231021059790N1

Enrollment

Registered

2024-08-01

Start date

2024-08-05

Completion date

Unknown

Last updated

2024-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The protective and antioxidant effect of adding N-acetylcysteine ??to del nido's cardioplegia solution in coronary artery surgeries. subsequent myocardial infarction, type 2

Interventions

Intervention 1: Intervention group: After fully connecting the patient to the cardiopulmonary pump, Del Nido's cardioplegia solution, which is electrolytically similar to the extracellular fluid and w

Eligibility

Sex/Gender

All

Age

39 Years to 70 Years

Inclusion criteria

Inclusion criteria: Patient consent to study study Age over 39 years and under 70 years No history of sternotomy and heart surgery Left ventricular ejection fraction greater than 30% Pulmonary outflow volume with pressure per second (FEV1) greater than 65% in spirometry Hemoglobin above 10 mg per deciliter

Exclusion criteria

Exclusion criteria: Need for drug support (receiving inotropes before starting heart surgery) Having a pacemaker Having impaired lung function tests for FEV1 less than 40% Having kidney or liver dysfunction Pump time more than 120 minutes Cross clamp less than 45 and more than 100 minutes Allergy to N-acetylcysteine

Design outcomes

Primary

Measure	Time frame
Type of heart rhythm. Timepoint: After removal of the aortic clamp. Method of measurement: ECG curve shape and heart rate per minute.;Return time of sinus rhythm of the heart. Timepoint: After removal of the aortic clamp. Method of measurement: Minutes.;Need for antiarrhythmic drugs. Timepoint: After removal of the aortic clamp. Method of measurement: Yes or no.;Consumption of inotropic after opening the aortic clamp. Timepoint: After removal of the aortic clamp. Method of measurement: Micrograms per kilogram per hour.;Requires defibrillator. Timepoint: After removal of the aortic clamp. Method of measurement: Yes or no.;Need a pacemaker. Timepoint: After removal of the aortic clamp. Method of measurement: Yes or no.;The amount of lactate. Timepoint: After separation of cardiopulmonary bypass machine. Method of measurement: Mg per liter.;Cardiac enzymes (troponin, Lactate Dehydrogenase and Creatine kinase-MB levels). Timepoint: Before surgery, 12 and 24 hours after surgery. Method of measurement: Micrograms per deciliter.;Heart ejection fraction. Timepoint: Before and after surgery. Method of measurement: Echo of the heart and in percent.;Glutathione peroxidase and Malonyl di aldehyde. Timepoint: Before the aortic clamp and 5 minutes after the opening of the aortic clamp from the coronary sinus. Method of measurement: coronary sinus blood samples in units per liter.;Duration of mechanical ventilation. Timepoint: Duration of the patient's arrivalafter surgery to the intensive care unit. Method of measurement: Hour.	—

Measure

Time frame

Type of heart rhythm. Timepoint: After removal of the aortic clamp. Method of measurement: ECG curve shape and heart rate per minute.;Return time of sinus rhythm of the heart. Timepoint: After removal of the aortic clamp. Method of measurement: Minutes.;Need for antiarrhythmic drugs. Timepoint: After removal of the aortic clamp. Method of measurement: Yes or no.;Consumption of inotropic after opening the aortic clamp. Timepoint: After removal of the aortic clamp. Method of measurement: Micrograms per kilogram per hour.;Requires defibrillator. Timepoint: After removal of the aortic clamp. Method of measurement: Yes or no.;Need a pacemaker. Timepoint: After removal of the aortic clamp. Method of measurement: Yes or no.;The amount of lactate. Timepoint: After separation of cardiopulmonary bypass machine. Method of measurement: Mg per liter.;Cardiac enzymes (troponin, Lactate Dehydrogenase and Creatine kinase-MB levels). Timepoint: Before surgery, 12 and 24 hours after surgery. Method of measurement: Micrograms per deciliter.;Heart ejection fraction. Timepoint: Before and after surgery. Method of measurement: Echo of the heart and in percent.;Glutathione peroxidase and Malonyl di aldehyde. Timepoint: Before the aortic clamp and 5 minutes after the opening of the aortic clamp from the coronary sinus. Method of measurement: coronary sinus blood samples in units per liter.;Duration of mechanical ventilation. Timepoint: Duration of the patient's arrivalafter surgery to the intensive care unit. Method of measurement: Hour.

—

Secondary

Measure	Time frame
Blood pressure. Timepoint: During the injection of cardioplegic solution. Method of measurement: Mm of mercury.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactKhadijeh Nazari

Shahid Rajaei Cardiovascular Hospital

kh.nazari9372@gmail.com+98 21 23921

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026