Traumatic brain injury. Intracranial injury
Conditions
Interventions
Intervention 1: Intervention group: patients in drug group will receive Coenzyme Q10 tablet (under license of Golden Life
Darman Yab Darou company), 600 mg daily for 3 days. Intervention 2: Control group: patients in control group will receive placebo (prepared in Faculty of Pharmacy) for 3 days.
Sponsors
Semnan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
16 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients aged 16 or above Patients with moderate or severe traumatic brain injury (Glasgow Coma Scale= 3-12) Admission to intensive care unit within 72 hours after brain injury Healthy gastrointestinal tract (capable of oral ingestion /gavage of drug) Not receiving warfarin
Exclusion criteria
Exclusion criteria: Hepatic failure (class C according to Child-pugh) Renal failure (need dialysis) Severe heart failure (class 3 and 4 according to New York heart association) Patients with sepsis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in biomarkers of oxidative stress (MDA, SOD). Timepoint: Days 1 and 3 of intervention. Method of measurement: ELISA kit.;Glasgow Coma Scale. Timepoint: Days 1 to 5. Method of measurement: GCS table.;Glasgow Outcome Scale. Timepoint: ??At the time of discharge from ICU and hospital. Method of measurement: GOS table. | — |
Secondary
| Measure | Time frame |
|---|---|
| Sequential Organ Failure Assessment (SOFA). Timepoint: Days 1, 3 and 5. Method of measurement: SOFA table.;Mortality rate of patients. Timepoint: After intervention until discharge from hospital. Method of measurement: Observation.;Length of hospitalization. Timepoint: At discharge day. Method of measurement: Number of hospitalization days. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMahdi Saghiri Ganjeh
Semnan University of Medical Sciences
Outcome results
None listed