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Comparison of the effect of Hypericum perforutum Vaginal gel and Clotrimazole Vaginal cream on Vaginal Candida albicans infection: A double-blind randomized clinical trial

Comparison of the effect of Hypericum perforutum Vaginal gel and Clotrimazole Vaginal cream on Vaginal Candida albicans infection: A double-blind randomized clinical trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20231017059753N1
Enrollment
80
Registered
2023-12-20
Start date
2023-11-22
Completion date
Unknown
Last updated
2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Candida vaginitis. Subacute and chronic vaginitis

Interventions

Intervention 1: The intervention group will use the vaginal gel of gerbera prepared by the pharmacist with a concentration of 3%. After manufacturing, it is poured into sterilized tubes and placed in

Sponsors

Yasouj University of Medical Sciences
Lead Sponsor
Vice President of Research and Technology of Yasouj University of Medical Sciences
Collaborator

Eligibility

Sex/Gender
Female
Age
18 Years to 49 Years

Inclusion criteria

Inclusion criteria: 1- Women of reproductive age (18-49)- 2- Presence of cheesy vaginal discharge and doctor's confirmation 3- Complaints of burning, itching and swelling and pain in the vulva and vagina 4- Absence of other vaginal infections 5- Willingness to participate in the study 6- Women with sexual partners

Exclusion criteria

Exclusion criteria: 1- Lactating women 2- Pregnant women 3- Women who smoke 4- The possibility of starting menstruation in the next 10 days 5- Having abnormal vaginal bleeding at the time of sampling 6- Having intercourse in the last 24 hours 7- Washing the vagina and using vaginal medicine in the last 48 hours 8- Having a history of any type of transplantation and using immunosuppressive drugs and broad-spectrum antibiotics, hormonal drugs and combined contraceptive pills, anti prostaglandins and anticoagulant drugs in the last month, and antiepileptic and migraine drugs or women with Heart and kidney diseases or sexually transmitted diseases. 9- History of Candida infection in the last 6 months and its treatment 10- History of candidal vaginitis

Design outcomes

Primary

MeasureTime frame
Itching. Timepoint: Results will be measured ten days to two weeks after the end of the treatment period. Method of measurement: The way to measure the variable will be through a laboratory test and also a researcher-made questionnaire of clinical symptoms.;Burning. Timepoint: Results will be measured ten days to two weeks after the end of the treatment period. Method of measurement: The way to measure the variable will be through a laboratory test and also a researcher-made questionnaire of clinical symptoms.;Vaginal pain. Timepoint: Results will be measured ten days to two weeks after the end of the treatment period. Method of measurement: The way to measure the variable will be through a laboratory test and also a researcher-made questionnaire of clinical symptoms.;Inflammation. Timepoint: Results will be measured ten days to two weeks after the end of the treatment period. Method of measurement: The way to measure the variable will be through a laboratory test and also a researcher-made questionnaire of clinical symptoms.;Cheesy secretions. Timepoint: Results will be measured ten days to two weeks after the end of the treatment period. Method of measurement: The way to measure the variable will be through a laboratory test and also a researcher-made questionnaire of clinical symptoms.

Secondary

MeasureTime frame
Satisfaction with treatment. Timepoint: One week to ten days after the intervention. Method of measurement: questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactLeila Bozorgian

Yasouj University of Medical Sciences

liela.bozorgian1@gmail.com+98 74 3323 0240

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026