Changes of betamethasone on non-stress test (NST) and Doppler ultrasound parameters in fetuses with growth restriction

The cheanges of betamethasone on non-stress test (NST) and Doppler ultrasound parameters in fetuses with Intra uterine growth retardation in pregnant women referred to Imam Khomeini Hospital in Sari

Status

Recruiting

Phases

Phase 1

Study type

Observational

Source

IRCT

Registry ID

IRCT20231015059721N1

Enrollment

Registered

2023-10-22

Start date

2023-10-22

Completion date

Unknown

Last updated

2023-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

In fetuses with growth restriction in pregnant women referred to Imam Khomeini Hospital in Sari. Z35.2

Interventions

Intervention group: Betamethasone receiving group.

Eligibility

Sex/Gender

Female

Age

14 Years to 55 Years

Inclusion criteria

Inclusion criteria: 1- Singleton pregnancy 2- Gestational age of 28 to 32 weeks and threat of preterm delivery 3- Fetal growth restriction confirmed by ultrasound based on fetal growth percentage

Exclusion criteria

Exclusion criteria: 1- Arrhythmia or fetal heart problems 2- Congenital anomaly of the fetus 3- Symptoms of active infection of the mother 4- Premature rupture of the amniotic sac (PPROM) 5-Pregnant women receiving benzodiazepines and narcotics 6- Women who give birth during the study 7- Mother's underlying diseases (hypertension, diabetes

Design outcomes

Primary

Measure	Time frame
Determination of Doppler ultrasound parameters of the umbilical artery and MCA, determination of the basic fetal heart rate and beat-to-beat variability of the fetal heart rate and the increase or decrease of the fetal heart rate. Timepoint: First, a non-stress test of NST for 20 minutes and Doppler of the umbilical MCA artery were performed for the patient, then 2 doses of betamethasone ampoule (12 mg) were injected into the patient at an interval of 24 hours. After 12 hours (day 1), 24 hours (day 2) and 36 hours (day 2), NST is performed again for 20 minutes. Time range of Doppler ultrasound (24 to 36 hours) after receiving two doses of betamethasone. Method of measurement: Demographic and clinical characteristics questionnaire, non-stress test before and 12, 24 and 36 hours after the injection of two doses of betamethasone and doppler ultrasound 24 to 36 hours after the injection of the first dose of betamethasone.	—

Measure

Time frame

Determination of Doppler ultrasound parameters of the umbilical artery and MCA, determination of the basic fetal heart rate and beat-to-beat variability of the fetal heart rate and the increase or decrease of the fetal heart rate. Timepoint: First, a non-stress test of NST for 20 minutes and Doppler of the umbilical MCA artery were performed for the patient, then 2 doses of betamethasone ampoule (12 mg) were injected into the patient at an interval of 24 hours. After 12 hours (day 1), 24 hours (day 2) and 36 hours (day 2), NST is performed again for 20 minutes. Time range of Doppler ultrasound (24 to 36 hours) after receiving two doses of betamethasone. Method of measurement: Demographic and clinical characteristics questionnaire, non-stress test before and 12, 24 and 36 hours after the injection of two doses of betamethasone and doppler ultrasound 24 to 36 hours after the injection of the first dose of betamethasone.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactZahra Rahmani

Mazandaran University of Medical Sciences

refah@mazums.ac.ir+98 11 3304 4000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026