comparison of the effect of the three methods of hemofiltration during CABG on kidney function

comparison of the effect of modified and conventional hemofiltration and combination of the two methods during cardiopulmonary bypass during coronary artery bypass graft surgery (CABG) on kidney function

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20231011059689N1

Enrollment

Registered

2023-10-16

Start date

2023-10-13

Completion date

Unknown

Last updated

2023-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

: Comparing the effect of hemofiltration with modified and conventional methods during heart and lung pumping on kidney function (24-hour urine volume, glomerular filtration rate and CrCl after surgery.

Interventions

Intervention 1: Intervention group: the group in which hemofiltration is performed by the common method (CUF/Conventional). In this group, during heart and lung bypass, the blood is transferred to the

Eligibility

Sex/Gender

All

Age

35 Years to 60 Years

Inclusion criteria

Inclusion criteria: patients between 35 and 60 years old consciously able to sign a consent letter for participating in this research a candidate for coronary artery bypass graft. recognized by a left ventricle ejection fraction of more than 45% recognized by a gloumeral filtarion rate between 70 and 120

Exclusion criteria

Exclusion criteria: patients recognized by a left ventricle ejection fraction of less than 45% recent MI a gloumeral filtration rate of less than 70 mili litrs per minute kidney failure serum creatinine of more than 1.3 miligrams per decilitr emergency surgery a history of diabetic nephropathy a conjoint valve surgery proteinuria

Design outcomes

Primary

Measure	Time frame
Serum creatinine. Timepoint: before coronary artery bupass graft surgery - 24 hours after CABG - 72 hours after CABG. Method of measurement: Collection of venous blood sample and measurement of serum creatinine in clinical laboratory.;Creatinine clearance. Timepoint: before coronary artery bupass graft surgery - 24 hours after CABG - 72 hours after CABG. Method of measurement: calculating the amount using the quantity of serum creatinine and the formula : CrCl(ml/min) = ((140-age)lean body weight(kg))/(serum creatinine(mg/dl)72) * (0.85 if female).;Gloumeral filtration rate. Timepoint: before coronary artery bupass graft surgery - 24 hours after CABG - 72 hours after CABG. Method of measurement: Calculation of the amount based on the amount of serum creatinine and a defined constant with the help of the Cockcroft-Gallt formula : eGFR=((140-age)weightconstant)/(serum creatinine) constant = 1.23 for men and 1.04 for women.	—

Measure

Time frame

Serum creatinine. Timepoint: before coronary artery bupass graft surgery - 24 hours after CABG - 72 hours after CABG. Method of measurement: Collection of venous blood sample and measurement of serum creatinine in clinical laboratory.;Creatinine clearance. Timepoint: before coronary artery bupass graft surgery - 24 hours after CABG - 72 hours after CABG. Method of measurement: calculating the amount using the quantity of serum creatinine and the formula : CrCl(ml/min) = ((140-age)*lean body weight(kg))/(serum creatinine(mg/dl)*72) * (0.85 if female).;Gloumeral filtration rate. Timepoint: before coronary artery bupass graft surgery - 24 hours after CABG - 72 hours after CABG. Method of measurement: Calculation of the amount based on the amount of serum creatinine and a defined constant with the help of the Cockcroft-Gallt formula : eGFR=((140-age)*weight*constant)/(serum creatinine) constant = 1.23 for men and 1.04 for women.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Mehran Shahzamani

Esfahan University of Medical Sciences

drshahzamani@yahoo.com0098 31 2600961

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026