Condition 1: Overweight and obesity. Condition 2: Activity, other involving cardiorespiratory exercise. Condition 3: Activity, exercise machines primarily for muscle strengthening. Condition 4: Body composition. Condition 5: Inflammation. Condition 6: mitochondrial dynamic. Overweight and obesity Activity, other involving cardiorespiratory exercise Activity, exercise machines primarily for muscle strengthening
Conditions
Interventions
Intervention 1: 1) Intervention group: Individuals with overweight and obesity undergo 12 weeks of combined exercise training and receive either daily vitamin C (1000 mg) and vitamin E (400 IU)
. Intervention 2: 2) Intervention group: Individuals with overweight and obesity undergo 12 weeks of combined exercise training and receive a placebo
. Intervention 3: 3) Intervention group: Healthy people undergo 12 weeks of combined exercise training and receive either daily vitamin C (1000 mg) and vitamin E (400 IU)
. Intervention 4: 4) Intervention group: Healthy people undergo 12 weeks of combined exercise training and receive a placebo.
Sponsors
INTERNATIONAL SCIENCE AND TECHNOLOGY UNIVERSITY
Eligibility
Sex/Gender
All
Age
18 Years to 30 Years
Inclusion criteria
Inclusion criteria: Ages: 18 - 30 years Body mass index: 18.9 - 35 kg/m2 Not engaged in regular exercise activities over the last six months No smoking or alcohol consumption No supplement use over the last six months
Exclusion criteria
Exclusion criteria: Suffering from chronic cardiovascular, liver and kidney diseases Having any pain or mobility limitations that prevent interventions Current treatment with medication or supplements that significantly affect the main study variables Having a history of bariatric surgery Following a special diet, including strict vegetarian/vegan, within the past 6 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Maximal oxygen consumption. Timepoint: Before and after 12 weeks of intervention as well as following a 3-month follow-up. Method of measurement: Using the Gas analyzer instrument.;Glucose homeostasis. Timepoint: Before and after 12 weeks of intervention as well as following a 3-month follow-up. Method of measurement: By measuring fasting glucose and insulin, HOMA-IR, HbA1c, and optional OGTT.;Body composition. Timepoint: Before and after 12 weeks of intervention as well as following a 3-month follow-up. Method of measurement: By Dual-Energy X-ray Absorptiometry (DXA).;Muscle strength. Timepoint: Before and after 12 weeks of intervention as well as following a 3-month follow-up. Method of measurement: Using an isometric back strength dynamometer. | — |
Secondary
| Measure | Time frame |
|---|---|
| Muscular mitochondrial markers. Timepoint: 48 hours after the last training session. Method of measurement: Using ELISA method.;Lipid profile. Timepoint: Before and after 12 weeks of intervention as well as following a 3-month follow-up. Method of measurement: Biochemical analysis.;Inflammatory factors. Timepoint: Before and after 12 weeks of intervention as well as following a 3-month follow-up. Method of measurement: Using ELISA method.;Oxidative stress. Timepoint: Before and after 12 weeks of intervention as well as following a 3-month follow-up. Method of measurement: Using ELISA method.;Plasma levels of fat browning factors. Timepoint: Before and after 12 weeks of intervention as well as following a 3-month follow-up. Method of measurement: Using ELISA method.;Muscle antioxidant regulators. Timepoint: 48 hours after the last training session. Method of measurement: Using ELISA method. | — |
Countries
Turkey
Contacts
Public ContactDavar Khodadadi
Islamic Azad University
Outcome results
None listed