Impact of chronic caffeine supplementation on exercise adaptations

Impact of chronic caffeine supplementation on high-intensity interval training–induced adaptations in physically inactive young men

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20231004059615N4

Enrollment

Registered

2025-06-04

Start date

2025-05-28

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Exercise adaptations.

Interventions

Intervention 1: Intervention group: Caffeine group that will take caffeine supplement (3 mg/kg/day) for 8 weeks. Intervention 2: Intervention group: Exercise group that will perform high-intensity int

Eligibility

Sex/Gender

Male

Age

18 Years to 25 Years

Inclusion criteria

Inclusion criteria: All young men between the ages of 18 and 25. Have complete physical and mental health. Do not smoke. Do not consume alcohol. Daily caffeine intake be less than 25 mg. Be physically inactive.

Exclusion criteria

Exclusion criteria: Suffering from pathology or injury Taking any medications or nutritional supplements within the past three months Missing > 5% of the training trials

Design outcomes

Primary

Measure	Time frame
Maximum oxygen consumption. Timepoint: Pre-test, mid-test and post-test. Method of measurement: Bruce test and gas analyzer.;Muscular strength. Timepoint: Pre-test, mid-test and post-test. Method of measurement: Dynamometer.;Muscular endurance. Timepoint: Pre-test, mid-test and post-test. Method of measurement: Repeated squat test.;Reaction time. Timepoint: Pre-test, mid-test and post-test. Method of measurement: Ruler test.;Concentration and attention. Timepoint: Pre-test, mid-test, and post-test. Method of measurement: Continuous performance test.;Anaerobic powers. Timepoint: Pre-test, mid-test, and post-test. Method of measurement: RAST TEST.;Speed. Timepoint: Pre-test, mid-test and post-test. Method of measurement: 36 m Test.	—

Measure

Time frame

Maximum oxygen consumption. Timepoint: Pre-test, mid-test and post-test. Method of measurement: Bruce test and gas analyzer.;Muscular strength. Timepoint: Pre-test, mid-test and post-test. Method of measurement: Dynamometer.;Muscular endurance. Timepoint: Pre-test, mid-test and post-test. Method of measurement: Repeated squat test.;Reaction time. Timepoint: Pre-test, mid-test and post-test. Method of measurement: Ruler test.;Concentration and attention. Timepoint: Pre-test, mid-test, and post-test. Method of measurement: Continuous performance test.;Anaerobic powers. Timepoint: Pre-test, mid-test, and post-test. Method of measurement: RAST TEST.;Speed. Timepoint: Pre-test, mid-test and post-test. Method of measurement: 36 m Test.

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Secondary

Measure	Time frame
CYP1A2 genotype. Timepoint: Pre-test. Method of measurement: restriction fragment length polymorphism-polymerase chain reaction method.;Mean distance traveled. Timepoint: During training sessions. Method of measurement: Total distance traveled / number of repetitions.;Fatigue index. Timepoint: During training sessions. Method of measurement: (longest distance - shortest distance) ? 100 / longest distance.;Body mass. Timepoint: Pre-test, mid-test, and post-test. Method of measurement: Body Composition Analyser.;Percent of body fat. Timepoint: Pre-test, mid-test, and post-test. Method of measurement: Body Composition Analyser.;Blood lipids. Timepoint: Pre-test, mid-test, and post-test. Method of measurement: Venous blood sampling and related kits.	—

Measure

Time frame

CYP1A2 genotype. Timepoint: Pre-test. Method of measurement: restriction fragment length polymorphism-polymerase chain reaction method.;Mean distance traveled. Timepoint: During training sessions. Method of measurement: Total distance traveled / number of repetitions.;Fatigue index. Timepoint: During training sessions. Method of measurement: (longest distance - shortest distance) ? 100 / longest distance.;Body mass. Timepoint: Pre-test, mid-test, and post-test. Method of measurement: Body Composition Analyser.;Percent of body fat. Timepoint: Pre-test, mid-test, and post-test. Method of measurement: Body Composition Analyser.;Blood lipids. Timepoint: Pre-test, mid-test, and post-test. Method of measurement: Venous blood sampling and related kits.

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Countries

Turkey

Contacts

Public ContactDavar Khodadadi

Islamic Azad University

davar.khodadadi@yahoo.com+98 21 2263 3583

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026