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The effect of circadian rhythm on exercise performance and homeostatic and metabolic responses to acute caffeine intake.

Effect of acute caffeine intake on exercise performance, hemostasis, and metabolism at different times of day

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20231004059615N2
Enrollment
120
Registered
2025-03-15
Start date
2025-03-25
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Obesity. Condition 2: cardiovascular disorders. Overweight and obesity Encounter for screening for cardiovascular disorders

Interventions

Intervention 1: First intervention group: Obesity
According to the crossover design, each subject will participate in 4 experimental sessions: 2 sessions in the morning and 2 sessions in the evening following caffeine (3 mg/kg) or placebo intake. Eac

Sponsors

INTERNATIONAL SCIENCE AND TECHNOLOGY UNIVERSITY
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
20 Years to 30 Years

Inclusion criteria

Inclusion criteria: Don't smoke. Do not consume alcohol. Have not taken any sports supplements in the past 6 months. Do not have a habit of consuming caffeine. Do not suffer from cardiovascular and hematological diseases. Healthy subjects should have a body mass index of 18.5 - 24.9. Obese subjects should have a body mass index = 30. Trained subjects should have a regular exercise history in the past 3 years. Untrained subjects should not have a history of regular exercise in the past 6 months.

Exclusion criteria

Exclusion criteria: Having caffeine habituation Cardiovascular and hematological diseases Having a physical injury that prevents from exercising. Having a body mass index of less than 18.5 and more than 24.9 for healthy subjects and less than 30 for obese subjects

Design outcomes

Primary

MeasureTime frame
Von Willebrand factor level. Timepoint: Before, immediately after, and 30 minutes after each exercise session. Method of measurement: ELISA.;VIII factor level. Timepoint: Before, immediately after, and 30 minutes after each exercise session. Method of measurement: ELISA.;Fibrinogen level. Timepoint: Before, immediately after, and 30 minutes after each exercise session. Method of measurement: Coagulometer.;Platelet count. Timepoint: Before, immediately after, and 30 minutes after each exercise session. Method of measurement: Blood cell counter.;Inhibitor of plasminogen activator type 1 (PAI-1) activity. Timepoint: Before, immediately after, and 30 minutes after each exercise session. Method of measurement: ELISA.;Tissue plasminogen activator (tPA) antigen level. Timepoint: Before, immediately after, and 30 minutes after each exercise session. Method of measurement: ELISA.;TPA activity. Timepoint: Before, immediately after, and 30 minutes after each exercise session. Method of measurement: ELISA.;Testosterone level. Timepoint: Before, immediately after, and 30 minutes after each exercise session. Method of measurement: ELISA.;Cortisol level. Timepoint: Before, immediately after, and 30 minutes after each exercise session. Method of measurement: ELISA.;Anaerobic power. Timepoint: At the end of each exercise session. Method of measurement: Wingate test.

Countries

Turkey

Contacts

Public ContactDavar Khodadadi

Islamic Azad University

davar.khodadadi@yahoo.com+98 21 2263 3583

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026