Non-alcoholic steatohepatitis. Nonalcoholic steatohepatitis (NASH)
Conditions
Interventions
Intervention 1: Intervention group:Patients with NASH are given 6 mg of melatonin, manufactured by Galenus Company, at night before bed for 12 weeks. Intervention 2: Control group: Patients with NASH
Sponsors
Galenos pharmaceutical company
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Age over 18 years Evidence in favor of non-alcoholic steatohepatic disease with sonography AST>30 IN men AST>19 IN female
Exclusion criteria
Exclusion criteria: Autoimmune disease Liver and biliary disease heart disease Diabetes Mellitus kidney disease Metabolic disease malignancy Hypothyroidism Cushing syndrome History of hepatitis pregnancy alcohol consumption Fatty liver grade 1
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fatty liver grade. Timepoint: 12week. Method of measurement: liver sonography. | — |
Secondary
| Measure | Time frame |
|---|---|
| Level insulin. Timepoint: The beginning of the study- 12 week. Method of measurement: unit.;Aspartate aminotransferase. Timepoint: The beginning of the study- 12 week. Method of measurement: Milli-international units per litre.;Alanine aminotransferase. Timepoint: The beginning of the study- 12 week. Method of measurement: Milli-international units per litre.;Fatty liver stage. Timepoint: The beginning of the study- 12 week. Method of measurement: Based on ultrasound, no/1/2/3.;Fasting blood suger. Timepoint: The beginning of the study- 12 week. Method of measurement: Milligrams Per Deciliter.;Study group. Timepoint: The beginning of the study- 12 week. Method of measurement: Intervention/control.;Fibrosis-4 Index. Timepoint: The beginning of the study- 12 week. Method of measurement: The number according to the formula. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactBahareh Mahjoubi Asil
Zahedan University of Medical Sciences
Outcome results
None listed