Toxic liver disease with fibrosis and cirrhosis of liver. Toxic liver disease with fibrosis and cirrhosis of liver
Conditions
Interventions
Intervention 1: Intervention group: patients who are given atorvastatin 40 mg and aspirin 80 mg once a day for one year. Intervention 2: Intervention group: patients who were given only atorvastatin 4
Sponsors
Zahedan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: - Patients with liver cirrhosis who were diagnosed with symptoms Age 18-75 Ultrasound based on cirrhosis
Exclusion criteria
Exclusion criteria: pregnant woman Statin use in the last year affected hcc LDL >70 Myopathy caused by atherostatin treatment meld>23 child pugh>13 Evidence of infection in the last 4 weeks Hepatornal syndrome in clinical and biochemical evidence in the last 14 days High hepatic encephalopathy 2 3 times increase of aminotransferase in 3 months after starting the study Recent use of febrate, varithromycin and others useP450 inhibitor Esophageal varices Patient dissatisfaction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CK: One of the body's muscle enzymes. Timepoint: Every three months to a year. Method of measurement: Measurements from the patient's blood sample.;AST :SGOT is an enzyme from the group of transferases. In fact, it is a PLP-dependent transaminase that is mainly found in the liver. Timepoint: Every three months to a year. Method of measurement: Measurements from the patient's blood sample.;It is an enzyme found mainly in the liver, but small amounts are also found in the kidneys, heart, muscles, and pancreas. (SGPT). Timepoint: Every three months to a year. Method of measurement: Measurements from the patient's blood sample.;PT:Blood clotting time. Timepoint: Every three months to a year. Method of measurement: Measurements from the patient's blood sample.;PLT:The number of platelets in the serum. Timepoint: Every three months to a year. Method of measurement: Measurements from the patient's blood sample. | — |
Secondary
| Measure | Time frame |
|---|---|
| Fib_4 index:Fibrosis index base on index-Non-invasive indicator of liver fibrosis. Timepoint: Every three months to a year. Method of measurement: It is calculated based on age and platelets and AST in the formula.;Non-invasive indicator of liver fibrosis-Ast to platlet retio index. Timepoint: Every three months to a year. Method of measurement: It is calculated based on AST and PLT in the formula. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactBahareh Mahjoubi Asil
Zahedan University of Medical Sciences
Outcome results
None listed