1- Sjogren's syndrome patients with severe dry eyes 2- Mustard gas chemical veterans with severe dry eyes. Other disorders of lacrimal gland (Dry eye syndrome )
Conditions
Interventions
Intervention 1: For the control group (Patients with Sjogren's syndrome and severe dry eye symptoms), conventional dry eye treatment methods such as artificial tear drops and topical corticosteroid dr
Sponsors
Bagheiat-allah University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients with Sjogren's syndrome and severe dry eyes, who do not respond well to conventional dry eye treatments chemical eye injuries caused by mustard gas and severe dry eyes, who do not respond well to conventional dry eye treatments low tear breakup time (less than 5 seconds) low Schirmer test results (5 mm) Positive fluorescein staining (=3)
Exclusion criteria
Exclusion criteria: Patients who have infection and inflammation not related to dry eye use of contact lenses eye allergies history of surgery and eyelid and eyelash abnormalities pregnant or breastfeeding women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severe dry eye sign and symptoms. Timepoint: before the intervention and 1 and 2 months after the intervention. Method of measurement: The dry eye symptom score of the patient is subjectively used from the Persian OSDI questionnaire, whose validity and reliability have been checked in the Iranian population. Tear film breakup time test is evaluated using slit lamp with cobalt blue filter and sodium fluorescein. The Schirmer test is performed using a standardized kit containing a 5 x 30 mm filter paper strip and placed on the lower eyelid margin in the temporal area. Fluorescein staining test of cornea and conjunctiva is evaluated and recorded based on SICCA (Sjogren's International Collaborative Clinical Alliance) criteria to assess the amount of tissue damage before treatment and one month and 2 months after treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual acuity status. Timepoint: Before the intervention and 1 and 2 months after the intervention, vision evaluation is done. Method of measurement: We record the acuity of patients based on the logarithm of the minimum angle of resolution (log MAR) at each follow-up. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHossein Aghamolai
Bagheiat-allah University of Medical Sciences
Outcome results
None listed