Brain function of people with depressive symptoms before and after tDCS, tPCS and cognitive rehabilitation interventions

Evaluation of QEEG indicators, neuropsychological characteristics and theory of mind in subjects with depressive symptoms: comparing the effectiveness of transcranial direct current stimulation (tDCS) and transcranial pulsed current stimulation (tPCS) with cognitive rehabilitation.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230922059489N1

Enrollment

Registered

2023-10-05

Start date

2023-10-23

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The participants in this research are people who are diagnosed with symptoms of depression after conducting clinical interviews and initial evaluations by a clinical psychologist. Also, the severity of depression symptoms will be based on the Beck Depression Inventory in three ranges (minimum depression, weak depression and moderate depression).. Mood disorder due to known physiological condition, unspecified

Interventions

Intervention 1: Intervention group: (Experimental group 1): tDCS is combined with cognitive rehabilitation. In this research, stimulation using the SegalStim device, through two positive and negative

Eligibility

Sex/Gender

All

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Suffering from depression based on; Clinical interview and psychologist's diagnosis as well as Beck Depression Inventory Not starting to take antidepressants No history of hospitalization and mood disorder Not having anxiety disorders No psychotic symptoms Not having a history of seizures and epilepsy being right-handed Age ranges from 18 to 40 years Have at least a high school diploma The person's agreement to participate in the research based on completing the informed consent form

Exclusion criteria

Exclusion criteria: The person's unwillingness to continue cooperation Absence of more than three consecutive sessions Taking antidepressants during the research process Occurrence of psychotic symptoms Occurrence of seizures and epilepsy History of hospitalization in a psychiatric hospital, psychiatric and psychological treatment at the same time as conducting research

Design outcomes

Primary

Measure	Time frame
In this research, in order to measure the symptoms of depression and better understand the changes in the level of depression symptoms before and after the desired interventions, the scores obtained in the Beck Depression Inventory (based on the severity of depression) are used. Timepoint: Evaluation and measurement of depression symptoms will be done at the beginning of the study (before the start of the intervention) and after 10 intervention sessions. Method of measurement: Beck Depression Inventory.;In the present study, in order to record brain waves and better understand the changes made in QEEG indicators (three-dimensional intra-brain distributions of current density for frequency bands, power changes, frequency bandwidth and brain wave asymmetry) of people with depression symptoms, Before and after the desired interventions, visible changes in Quantitative Electroencephalography recording are used. Timepoint: QEEG indicators will be evaluated at the beginning of the study (before the intervention) and after 10 intervention sessions. Method of measurement: Quantitative Electroencephalography(QEEG).;In this research, in order to measure and better understand the changes in neuropsychological characteristics (verbal working memory, visuospatial working memory, planning, set shifting (mental flexibility), inhibition and sustained attention) of people with symptoms Depression, before and after the desired interventions, the scores obtained in the computerized cognitive tests and Barkley Deficits in Executive Functioning Scale are used. Timepoint: Evaluation of neuropsychological characteristics will be done at the beginning of the study (before the start of the intervention) and after 10 intervention sessions. Method of measurement: Digit Span, Corsi Blocks Test, Tower of London Test, Wisconsin Card Sorting Test, Go/No-Go, Continuous Performance Test and Barkley Deficits in Executive Functioning Scale.;In this research, in order to measure and better understand	—

Measure

Time frame

In this research, in order to measure the symptoms of depression and better understand the changes in the level of depression symptoms before and after the desired interventions, the scores obtained in the Beck Depression Inventory (based on the severity of depression) are used. Timepoint: Evaluation and measurement of depression symptoms will be done at the beginning of the study (before the start of the intervention) and after 10 intervention sessions. Method of measurement: Beck Depression Inventory.;In the present study, in order to record brain waves and better understand the changes made in QEEG indicators (three-dimensional intra-brain distributions of current density for frequency bands, power changes, frequency bandwidth and brain wave asymmetry) of people with depression symptoms, Before and after the desired interventions, visible changes in Quantitative Electroencephalography recording are used. Timepoint: QEEG indicators will be evaluated at the beginning of the study (before the intervention) and after 10 intervention sessions. Method of measurement: Quantitative Electroencephalography(QEEG).;In this research, in order to measure and better understand the changes in neuropsychological characteristics (verbal working memory, visuospatial working memory, planning, set shifting (mental flexibility), inhibition and sustained attention) of people with symptoms Depression, before and after the desired interventions, the scores obtained in the computerized cognitive tests and Barkley Deficits in Executive Functioning Scale are used. Timepoint: Evaluation of neuropsychological characteristics will be done at the beginning of the study (before the start of the intervention) and after 10 intervention sessions. Method of measurement: Digit Span, Corsi Blocks Test, Tower of London Test, Wisconsin Card Sorting Test, Go/No-Go, Continuous Performance Test and Barkley Deficits in Executive Functioning Scale.;In this research, in order to measure and better understand

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Secondary

Measure	Time frame
In the present study, in order to measure and better understand the changes in the level of emotional problems of people with depressive symptoms before and after the desired interventions, from the scores obtained in Positive Affect and Negative Affect Scales(PANAS)and Multidimensional Emotional Disorder Inventory (MEDI) is used. Timepoint: Evaluation and measurement of emotional problems is done at the beginning of the study (before the start of the intervention) and after 10 sessions of the intervention. Method of measurement: Positive Affect and Negative Affect Scales(PANAS), Multidimensional Emotional Disorder Inventory (MEDI).	—

Measure

Time frame

In the present study, in order to measure and better understand the changes in the level of emotional problems of people with depressive symptoms before and after the desired interventions, from the scores obtained in Positive Affect and Negative Affect Scales(PANAS)and Multidimensional Emotional Disorder Inventory (MEDI) is used. Timepoint: Evaluation and measurement of emotional problems is done at the beginning of the study (before the start of the intervention) and after 10 sessions of the intervention. Method of measurement: Positive Affect and Negative Affect Scales(PANAS), Multidimensional Emotional Disorder Inventory (MEDI).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactFatemeh Ghanaei Chamanabad

Ferdowsi University of Mashhad

fa.ghanaeechamanabad@um.ac.ir+98 51 3423 1013

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026