Acne. Acne vulgaris
Conditions
Interventions
Intervention 1: Intervention group (group A): combination of doxycycline Hakim company 100 mg once daily and N-acetyl cysteine 5% gel once daily for 3 months. For preparing N-acetyl cysteine 5% gel w
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
15 Years to 35 Years
Inclusion criteria
Inclusion criteria: patients with moderate Acne married females who agree with taking oral contraceptive pills (OCP) during treatment
Exclusion criteria
Exclusion criteria: below 15 or over 35 years old unwillingness to participate in the study inability to come regularly for follow-up visits use of herbal medicine receiving systemic anti acne therapies 1 month before the study receiving topical anti acne therapies 2 weeks before the study pregnancy and breast feeding hepatic diseases renal diseases use of nitroglycerine use of medications that have interaction with the drugs used in the study history of hypersensitivity to the medications used in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Acne severity. Timepoint: 1 and 3 month later. Method of measurement: according to Investigator Global Assessment (IGA) score.;Acne severity. Timepoint: 1 and 3 months later. Method of measurement: according to Global Acne Grading System (GAGS) score. | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of life improvement. Timepoint: 1 and 3 months later. Method of measurement: Cardiff Acne Disability Index (CADI) quality of life questionnaire.;Treatment response. Timepoint: after 3 months. Method of measurement: question the patients. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNegin Fazelzadeh Haghighi
Shiraz University of Medical Sciences
Outcome results
None listed