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Addition of neostigmine and atropine to standard post-dural puncture headache

Comparison between neostigmine and atropine added to standard post-dural puncture headache regimen versus standard regimen alone

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20230920059483N1
Enrollment
130
Registered
2024-02-10
Start date
2023-01-01
Completion date
Unknown
Last updated
2024-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post dural puncture headache. Other headache syndromes

Interventions

Intervention 1: Intervention group: Group M (Modified regimen group) Patients in the modified regimen received the same protocol and drugs of the standard regimen as well as IV neostigmine 20 mcg/kg a

Sponsors

Combined Military Hospital Kharian, Pakistan
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
25 Years to 35 Years

Inclusion criteria

Inclusion criteria: Included all patients with post-dural puncture headache diagnosed according to the International Headache Society Criteria, presenting to the anesthesia clinic 48-72 hours after caesarian delivery.

Exclusion criteria

Exclusion criteria: Patients unwilling for IV or oral therapy Refusal to be included in the study Patients with allergy to either atropine, neostigmine, paracetamol and/or ibuprofen Patients with known history of migraine, cluster headache, patients on anti-depressants Patients with any neurological disease and patients with major respiratory and cardiac disease.

Design outcomes

Primary

MeasureTime frame
Pain on Visual Analog Scale. Timepoint: 6,12,24,48,72 hours after intervention. Method of measurement: Standard Visual Analog Scale.

Secondary

MeasureTime frame
Nausea. Timepoint: Within 72 hours after intervention. Method of measurement: Patient history and observation in the wards.;Neck stiffness. Timepoint: Within 72 hours after intervention. Method of measurement: Physical examination.;Need for blood patch. Timepoint: Within 72 hours of intervention. Method of measurement: Non-responsive to standard IV treatment after 24 hours.

Countries

Pakistan

Contacts

Public ContactDr Qaim Ali Bhatti

Combined Military Hospital Kharian

qaimalibhatty@gmail.com+92 331 6333113

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026