Comparison of acetaminophen and ibuprofen in the closure of PDA

Comparison of the effects of acetaminophen and ibuprofen in the treatment of infants with PDA admitted to Ali Ibn Abi Taleb Hospital in 2025

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230917059446N1

Enrollment

100

Registered

2025-10-03

Start date

2025-10-21

Completion date

Unknown

Last updated

2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patent ductus arteriosus (PDA). Patent ductus arteriosus

Interventions

Intervention 1: Control group: patients with PDA treated with acetaminophen. Injectable acetaminophen from Aburihan Pharmaceutical Company is used at a dose of 10 mg per kilogram of body weight fo

Eligibility

Sex/Gender

All

Age

1 Days to 30 Days

Inclusion criteria

Inclusion criteria: All hospitalized neonates with PDA

Exclusion criteria

Exclusion criteria: Neonates with another congenital heart disease hospitalized

Design outcomes

Primary

Measure	Time frame
Closed ductus arteriosus in echocardiography. Timepoint: After 5 days of drug treatment, echocardiography is performed on the 6th day to check the closure of the ductus arteriosus. Method of measurement: Echocardiography.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Alireza Ansari moghaddam

Zahedan University of Medical Sciences

dr_noori_cardio@yahoo.com+98 54 3329 5571

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026