Comparison of effect of methadone and methadone adjuvant Olanzapine on treatment in heroin and methamphetamine dependents with Novelty seeking temperament

Comparison of the effectiveness of methadone and temperament-based pharmacotherapy on treatment retention, relapse, and treatment boredom in heroin and methamphetamine dependents

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230914059433N1

Enrollment

Registered

2023-10-12

Start date

2023-04-04

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: methamphetamine dependents. Condition 2: heroin dependents. Adverse effect of amphetamines Poisoning by and adverse effect of heroin

Interventions

Intervention 1: Intervention group:Methadon meintenance therapy adjuctive temprament-based psychopharmacotherapy with 5-10 mg olanzapine orally daily .In this group, people are treated with methadone

Eligibility

Sex/Gender

All

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Consent to participate in the study All dependent patients on heroin and meth-amphetamine Having Novelty seeking temperament Age 18 to 45 years Having desire to methadone maintenance treatment

Exclusion criteria

Exclusion criteria: Having past history of medical complication after use antipsychotic Having past history of Renal and liver disease Having past history of Heart disease

Design outcomes

Primary

Measure	Time frame
Boredom. Timepoint: 6 months. Method of measurement: Boredom questionnaire.;Relapse. Timepoint: 6 months. Method of measurement: Urine anlysis.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactRastibarzoki Akram

Arak University of Medical Sciences

akrmrastybrzky@gmail.com+98 86 3313 7948

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026