Flatulence. Flatulence
Conditions
Interventions
Intervention 1: Intervention group: Patients in this group receive metronidazole 500 mg every 8 hours for 2 weeks. Then regflor probiotic containing 200 mg of active lyophilized Bifidobacterium infect
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Age between 18 and 70 years Having functional flatulence (based on Rome III criteria based on history and risk symptoms and functional flatulence diagnostic criteria) Abdominal flatulence feeling at least 3 days a month in the last 3 months The first experience of flatulence is more than 6 months before the study Informed written consent to participate in the study
Exclusion criteria
Exclusion criteria: Any history of chronic inflammatory disease or structural disease of the gastrointestinal tract Any serious physical problem or disease such as inflammation or malignancy Use of calcium channel blocking drugs in the last 3 months Positive family history for colon cancer Celiac disease Any receipt of antibiotics or probiotics 8 weeks before the study Pregnancy or breastfeeding alcohol consumption
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bloating severity score. Timepoint: Before of the intervention, 2, 4, 6 and 8 weeks after the start of the study. Method of measurement: Questionnaire IBS- QOL.;Quality of life. Timepoint: Before of the intervention, 2, 4, 6 and 8 weeks after the start of the study. Method of measurement: Questionnaire IBS- QOL. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactElham Tabesh
Esfahan University of Medical Sciences
Outcome results
None listed