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Study of helping to improve shortness of breath and effusion volume in patients with malignant pleural effusion

Evaluation of the Effect of Intrapleural Administration of an Optimized Measles Vaccine on Dyspnea Improvement and Effusion Volume in Patients with Malignant Pleural Effusion

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
IRCT
Registry ID
IRCT20230903059342N5
Enrollment
10
Registered
2026-05-23
Start date
2026-06-21
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Malignant pleural effusion. Malignant pleural effusion

Interventions

Intervention group: In addition to standard treatment, patients receive the optimized measles vaccine product designed and optimized by Baqiyatallah University intrapleurally. Simultaneously with trea

Sponsors

Bagheiat-allah University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with malignant pleural effusion Patient age over 18 years Absence of pregnancy Proper functioning of liver, kidney and bone marrow The ability to understand and sign the consent form by the patient and one of these cases: the patient's spouse, parent or guardian. Complying with all protocol steps including sample submission and returning to the clinical study site for subsequent visits Absence of autoimmune diseases or diseases of the immune system

Exclusion criteria

Exclusion criteria: Life-threatening acute infection Absence of any previous record that describes the doctor's treatment and orders were nor followed by patient. Using drugs that weaken the immune system Affected by any diseases that disturbs the immune system Having any previous record of organ transplantation Allergy to measles vaccine pregnancy Using other investigational treatments at the same time

Design outcomes

Primary

MeasureTime frame
Fever. Timepoint: Hourly in the first 24 hours and then daily up to 7 days. Method of measurement: Thermometer.;Examining changes in the patient's heart condition. Timepoint: Examining changes in the patient's heart condition. Method of measurement: Electrocardiogram.;Examining changes in the patient's breathing status. Timepoint: Hourly in the first 24 hours and then daily up to 7 days. Method of measurement: pulse oximeter.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactRuhollah Dorostkar

Bagheiat-allah University of Medical Sciences

R.dorost@yahoo.com+98 21 8817 0179

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026