Effect of Cotton boll extract in treatment of Cutaneous leishmaniasis

Evaluating the effectiveness of intralesional injection of Glucantime® plus cotton boll extract compared to intralesional injection of Glucantime® plus cryotherapy in patients infected with Leishmania tropica

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230903059337N2

Enrollment

Registered

2023-10-24

Start date

2023-12-22

Completion date

Unknown

Last updated

2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cutaneous leishmaniasis. Cutaneous leishmaniasis

Interventions

Intervention 1: Intervention group: Intralesional injection of Glucantime® weekly for 8 weeks plus topical use of 10% Cotton boll extract twice a day for 8 weeks. Intervention 2: Control group: Intral

Eligibility

Sex/Gender

All

Age

8 Years to 60 Years

Inclusion criteria

Inclusion criteria: patients infected by Leishmania tropica Number of skin lesions less than 5 Size of lesions less than 5 centimeters Duration of lesions less than 3 months Receiving no anti-leishmania remedies during the past 3 months Completing the informed consent form

Exclusion criteria

Exclusion criteria: Pregnancy and Lactation Underlying diseases and Allergy Lesions on joint, face and sensitive organs Regional adenopathy

Design outcomes

Primary

Measure	Time frame
Size of induration. Timepoint: In 0, 4, 8, 12 weeks of treatment. Method of measurement: By digital caliper.;Size of wound. Timepoint: In 0, 4, 8, 12 weeks of treatment. Method of measurement: Wound Desk app and digital caliper.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMehdi Shafiei_bafti

Iran University of Medical Sciences

kmushafiei51@gmail.com+98 21 5558 0388

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026