Atrial fibrillation. Paroxysmal atrial fibrillation
Conditions
Interventions
Intervention 1: Patients receiving melatonin 10 mg tablets at night, 1 tablet from 3 days before surgery to 5 days after surgery. Intervention 2: Control group: Patients receiving placebo, 1 tablet at
Sponsors
Karaj University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients aged 18 years or older, whose blood supply disorder to the heart makes them candidates for coronary artery baypass grafting surgery Signing the consent form by the patient or the patient's qualified companion
Exclusion criteria
Exclusion criteria: People with a history of atrial fibrillation People with a history of allergic reactions to melatonin or other ingredients in the tablet People with the inability to swallow the oral form of melatonin in tablet form People with unstable hemodynamics before surgery People undergoing heart valve surgery at the same time Emergency coronary artery bypass surgery People with a previous history of any supraventricular arrhythmia Use of antiarrhythmic drugs People with kidney failure People with chronic liver disease Pregnant or lactating women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of people who suffer from atrial fibrillation after coronary artery bypass surgery. Timepoint: The incidence of atrial fibrillation after surgery in the first five days after CABG surgery. Method of measurement: Atrial fibrillation is diagnosed based on the absence of distinct repetitive P waves followed by irregular RR intervals lasting at least 30 seconds on a 12-lead ECG obtained from the patient. | — |
Secondary
| Measure | Time frame |
|---|---|
| Examining the levels of CK-MB enzyme; troponin protein and hs-CRP. Timepoint: From one day before the operation to the first 5 days after the operation. Method of measurement: Checking the results of laboratory measurements and the information recorded in the patient's file.;Duration of atrial fibrillation after surgery. Timepoint: Daily from the day after surgery. Method of measurement: Counting the number of days a person has atrial fibrillation after coronary artery bypass surgery and recording information based on the patient's file.;Duration of hospitalization in the intensive care unit. Timepoint: Daily from the day after surgery. Method of measurement: Counting the number of days a person is hospitalized in the intensive care unit of the hospital after surgery and based on the patient's admission file.;Duration of hospitalization. Timepoint: Daily from the day after surgery. Method of measurement: Counting the number of days a person is hospitalized and based on the patient's admission file. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactPantea Parandeh
Karaj University of Medical Sciences
Outcome results
None listed