Investigating the neuroprotective effect of erythropoietin in severe brain trauma

Investigating the neuroprotective effect of erythropoietin in patients with severe traumatic brain injury

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230901059316N1

Enrollment

136

Registered

2024-01-16

Start date

2024-01-21

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Severe brain trauma.

Interventions

Intervention 1: Intervention group: 100 mg per kilogram of erythropoietin in six hours of arrival and then repeated in the third, sixth, ninth and twelfth days. Intervention 2: Control group: Injectio

Eligibility

Sex/Gender

All

Age

15 Years to 70 Years

Inclusion criteria

Inclusion criteria: Patients with brain trauma with GCS consciousness less than eight who have been treated medically Less than six hours have passed since the patient's trauma

Exclusion criteria

Exclusion criteria: Chronic coagulation disorders Chronic kidney disease History of DVT and pulmonary embolism

Design outcomes

Primary

Measure	Time frame
The effect of erythropoietin on increased alertness is measured by periodic examinations based on a score from GCS (Glasgow coma scale). Timepoint: Six weeks and six months after the intervention. Method of measurement: Glasgow coma scale ,Glasgow outcome scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAfshin eslamirad

Mashhad University of Medical Sciences

afshin.eslamirad19122@gmail.com+98 51 3859 2121

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026