Sedation in ICU patients.
Conditions
Interventions
Intervention 1: Intervention group 1: Group A will receive ?Dexmedetomidine with a loading dose of 1 µg/kg for 10 minutes followed by a maintenance infusion of 5 µg/kg/hr (0.2-0.7 µg/kg/hr). If the ta
A propofol bolus of 0.2 mg/kg will be injected for a maximum of three consecutive boluses at an interval of 3 to 5 minutes. Intervention 2: Intervention group 2: Group B will receive Propofol with an
A propofol bolus of 0.2 mg/kg will be injected for a maximum of three consecutive boluses at an interval of 3 to 5 minutes.
Sponsors
Babol University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: patients over 18 years old staying in ICU for at least 24 hours after surgery need to be intubated and be sedated
Exclusion criteria
Exclusion criteria: Hypotension (SBP<90) pregnant women obesity (body weight more than 50% higher than ideal body weight) ESRD patients Glasgow Coma Scale (GCS) below 12 (moderate and severe brain damage) Significant arrhythmia or high degree of atrioventricular node block patients who are allergic to the drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of the need for narcotic drug (fentanyl) in dexmedetomidine and propofol groups. Timepoint: The amount of injected fentanyl will be measured at the end of 24 hours. Method of measurement: The amount of fentanyl injection will be recorded during the study. | — |
Secondary
| Measure | Time frame |
|---|---|
| Respiratory parameters (respiratory rate, spontaneous breathing and airway pressure). Timepoint: Respiratory parameters will be recorded at intervals of 30 minutes, 1 hour, 3 hours, 6 hours, 12 hours and 24 hours. Method of measurement: The mentioned variables are measured by ventilator devices and then recorded at the time intervals.;Level of consciousness. Timepoint: The level of consciousness will be recorded at intervals of 30 minutes, 1 hour, 3 hours, 6 hours, 12 hours and 24 hours. Method of measurement: The level of consciousness will be measured by Ramsay Sedation Scale.;Hemodynamic parameters (systolic and diastolic blood pressure, heart rate, mean arterial blood pressure). Timepoint: Hemodynamic parameters will be recorded at intervals of 30 minutes, 1 hour, 3 hours, 6 hours, 12 hours and 24 hours. Method of measurement: The monitoring device. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAmir Hossein Saadati
Babol University of Medical Sciences
Outcome results
None listed