Investigating the effect of dexmedetomidine drug administration on hemodynamic changes and sedation after heart surgery in opium addicted patients

Investigating the effect of dexmedetomidine drug infusion on hemodynamic changes and sedation after coronary bypass surgery (CABG)in opuim addict patients

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230825059256N1

Enrollment

112

Registered

2023-09-07

Start date

2023-09-23

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Coronary artery bypass surgery. Condition 2: addiction to opiod. Atherosclerotic cardiovascular disease, so described Opioid abuse

Interventions

Intervention 1: Intervention group: receiving dexmedtomidinmin 0.2 µg/kg/h. Intervention 2: Control group: receiving normal saline 0.2 µg/kg/h.

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Drug addiction (opium, methadone and syrup) based on DSM-V criteria Patients undergoing on-pump heart surgery Stable hemodynamics Patients without cardiac pacemaker Absence of liver and kidney disorders Patients willing to participate in the study

Exclusion criteria

Exclusion criteria: Bradycardia with a rate less than 60 beats per minute Unstable hemodynamics People who need high-dose vasoconstrictor drugs profuse bleeding Disagreement to continue cooperation in the study by the first degree companions

Design outcomes

Primary

Measure	Time frame
Hemodynamic changes. Timepoint: At the beginning, 3, 6, 8 and 12 hours after the operation. Method of measurement: Monitoring device.;Relaxation. Timepoint: At the beginning, 3, 6, 8 and 12 hours after the operation. Method of measurement: modified Ramsay scores.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactArsalan Eskandari Damaneh

Kerman University of Medical Sciences

arsalaneskandaridamaneh55@gmail.com+98 34 3214 1461

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026