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The effect of gel containing silver nanoparticles and triamcinolone ointment on the healing of lichen planus lesions

Comparison between of the effect triamcinolone oral paste and silver nanoparticles gel on the lichen planus lesions healing in human model

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20230823059242N1
Enrollment
40
Registered
2024-06-03
Start date
2023-09-23
Completion date
Unknown
Last updated
2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

lichen planus. lichen planus

Interventions

Intervention 1: Intervention group: gel containing silver nanoparticles (Made By US-NANO), some gel is placed on the affected area three times a day after meals for 5 minutes. The treatment is done fo

Sponsors

Shiraz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Definitive diagnosis of lichen planus using clinical method and pathological tissue sampling Type of erosive/atrophic lichen planus Absence of dysplasia

Exclusion criteria

Exclusion criteria: Pregnant women Injuries in contact with amalgam The use of drugs that cause lycanoid reactions Any treatment that has been done for these injuries Use of immunosuppressive drugs A history of sensitivity to silver and the presence of any systemic disease

Design outcomes

Primary

MeasureTime frame
Recovery rate. Timepoint: At intervals of 2, 4 and 8 weeks after the intervention. Method of measurement: It will be evaluated based on the classification and criteria of Tangprasum. The classification of the clinical criteria of Tangprasum is as follows: 0) harmless 1) mild white lines without inflammatory areas 2) white lines with atrophic areas smaller than one square centimeter 3) white lines with atrophic areas larger than one square centimeter 4 (white lines with erosive areas smaller than one square centimeter 5) white lines with erosive areas larger than one square centimeter or with ulcerative lesions.;Pain. Timepoint: At intervals of 2, 4 and 8 weeks after the intervention. Method of measurement: Postoperative pain will be evaluated using a visual analog scale (VAS), with 10 ratings, from 0 for "no pain" to 10 for "worst possible pain".

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFateme Beheshti

Shiraz University of Medical Sciences

fatemebeheshticync@gmail.com+98 71 3626 3193

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026