Ozone injection combined with hyaluronic acid compared to hyaloronic injection in the treatment of knee osteoarthritis

Investigating the effects of ozone injection combined with hyaluronic acid compared to hyaluronic injection in the treatment of knee osteoarthritis in patients referred to the orthopedic clinic and the pain clinic of Fatemi Ardabil Hospital.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230823059241N1

Enrollment

Registered

2023-09-27

Start date

2023-10-23

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoartritis in knee. Osteoarthritis of knee

Interventions

Intervention 1: Intervention group: 2 cc of intra-articular hyaluronic acid (Nitca company, 2 mg) on three occasions with an interval of one week. Intervention 2: Intervention group: 2 cc of intra-art

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Osteoartitis grade 1&2

Exclusion criteria

Exclusion criteria: Pregnancy or breastfeeding Taking anticoagulants Intra-articular drug use during the last 6 months History of knee surgery

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: The moment of entry, the second week, the second month and the sixth month after the intervention. Method of measurement: Visual Analog Scale.	—

Secondary

Measure	Time frame
Quality of Life. Timepoint: The moment of entry, the second week, the second month and the sixth month after the intervention. Method of measurement: SF-36 questionnaire.;Sleep quality. Timepoint: The moment of entry, the second week, the second month and the sixth month after the intervention. Method of measurement: Pittsburgh Questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Asayeshi

Ardabil University of Medical Sciences

maryamasayeshi88@gmail.com+98 45 3323 2520

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026