The effect of epigallocatechin gallate loaded nanostructured lipid carriers on oral lichen planus

The effect of epigallocatechin gallate (extracted from green tea) loaded nanostructured lipid carriers on the treatment of oral lichen planus

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230823059238N1

Enrollment

Registered

2023-09-18

Start date

2023-09-26

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

oral lichen planus. Other lichen planus

Interventions

Intervention 1: Intervention group: Mouthwash containing Epigallocatechin gallate loaded nanostructured lipid carriers will be used 3 times a day, 5 cc each time for 4 weeks. Intervention 2: Control g

Eligibility

Sex/Gender

All

Age

17 Years to 70 Years

Inclusion criteria

Inclusion criteria: Definite Diagnosis of Lichen Planus via Clinial criteria and Histopathology approvement Range of 17 to 70 years old

Exclusion criteria

Exclusion criteria: Pregnancy or breastfeeding Usage of Immuno supressor Drugs Any treatment that has been done for these injuries

Design outcomes

Primary

Measure	Time frame
Severity of pain. Timepoint: Before the start of the intervention and 2 and 4 weeks after the intervention. Method of measurement: The severity of pain will be evaluated through visual analogue scale (VAS).;The size of lesions. Timepoint: Before the start of the intervention and 2 and 4 weeks after the intervention. Method of measurement: The size of lesions will be measured with paper lace.;The appearance of lesions. Timepoint: Before the start of the intervention and 2 and 4 weeks after the intervention. Method of measurement: The appearance of lesions will be measured by Thongprasom scale and includes 6 grades: zero = perfectly healthy, 1 = mild white lines without inflammatory regions, 2 = white lines with atrophic regions smaller than 1 cm2, 3 = white lines with atrophic regions larger than 1 cm2, 4 = white lines accompanied with erosive regions less than 1 cm2, 5 = white lines with erosive areas larger than 1 cm2 .	—

Measure

Time frame

Severity of pain. Timepoint: Before the start of the intervention and 2 and 4 weeks after the intervention. Method of measurement: The severity of pain will be evaluated through visual analogue scale (VAS).;The size of lesions. Timepoint: Before the start of the intervention and 2 and 4 weeks after the intervention. Method of measurement: The size of lesions will be measured with paper lace.;The appearance of lesions. Timepoint: Before the start of the intervention and 2 and 4 weeks after the intervention. Method of measurement: The appearance of lesions will be measured by Thongprasom scale and includes 6 grades: zero = perfectly healthy, 1 = mild white lines without inflammatory regions, 2 = white lines with atrophic regions smaller than 1 cm2, 3 = white lines with atrophic regions larger than 1 cm2, 4 = white lines accompanied with erosive regions less than 1 cm2, 5 = white lines with erosive areas larger than 1 cm2 .

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahyar Hashemi

Tabriz University of Medical Sciences

mahyarmh77@gmail.com+98 41 3335 5965

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026