Investigating the effect of curcumin-piperine supplementation on interleukin 6 and oxidative stress index in diabetic nephropathy patients

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230823059232N2

Enrollment

Registered

2024-05-16

Start date

2024-05-21

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetic patients with nephropathy. Diabetes mellitus due to underlying condition

Interventions

Intervention 1: Intervention group: 500m/gram curcumin per day for 3 months. Intervention 2: Control group: Placebo (500 mg of lactose) to be consumed daily for 3 months.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Age =18 years Type 2 diabetes and nephropathy Estimated glomerular filtration rate (eGFR) =30 mL/min/1.73 m2 Controlled HTN (systolic). blood pressure [BP] <140 and diastolic blood pressure <90)

Exclusion criteria

Exclusion criteria: History of gallstones and biliary obstruction Kidney transplant treatment Autoimmune disease or malignancy pregnancy liver damage History of organ transplantation

Design outcomes

Primary

Measure	Time frame
Fasting blood suger. Timepoint: From the beginning of the study (before the start of the intervention) and 90 days after the start of the curcumin-piperine supplement. Method of measurement: Enzymatic method using a kit.;Creatinine. Timepoint: From the beginning of the study (before the start of the intervention) and 90 days after the start of the curcumin-piperine supplement. Method of measurement: Enzymatic method using a kit.;Urine albumine. Timepoint: From the beginning of the study (before the start of the intervention) and 90 days after the start of the curcumin-piperine supplement. Method of measurement: Turbidometry.;Malondialdehyde. Timepoint: From the beginning of the study (before the start of the intervention) and 90 days after the start of the curcumin-piperine supplement. Method of measurement: Eliza.;Superoxide dismutase. Timepoint: From the beginning of the study (before the start of the intervention) and 90 days after the start of the curcumin-piperine supplement. Method of measurement: eliza.;Interleukin 6. Timepoint: From the beginning of the study (before the start of the intervention) and 90 days after the start of the curcumin-piperine supplement. Method of measurement: eliza.;HbA1C. Timepoint: From the beginning of the study (before the start of the intervention) and 90 days after the start of the curcumin-piperine supplement. Method of measurement: Enzymatic method using a kit.	—

Measure

Time frame

Fasting blood suger. Timepoint: From the beginning of the study (before the start of the intervention) and 90 days after the start of the curcumin-piperine supplement. Method of measurement: Enzymatic method using a kit.;Creatinine. Timepoint: From the beginning of the study (before the start of the intervention) and 90 days after the start of the curcumin-piperine supplement. Method of measurement: Enzymatic method using a kit.;Urine albumine. Timepoint: From the beginning of the study (before the start of the intervention) and 90 days after the start of the curcumin-piperine supplement. Method of measurement: Turbidometry.;Malondialdehyde. Timepoint: From the beginning of the study (before the start of the intervention) and 90 days after the start of the curcumin-piperine supplement. Method of measurement: Eliza.;Superoxide dismutase. Timepoint: From the beginning of the study (before the start of the intervention) and 90 days after the start of the curcumin-piperine supplement. Method of measurement: eliza.;Interleukin 6. Timepoint: From the beginning of the study (before the start of the intervention) and 90 days after the start of the curcumin-piperine supplement. Method of measurement: eliza.;HbA1C. Timepoint: From the beginning of the study (before the start of the intervention) and 90 days after the start of the curcumin-piperine supplement. Method of measurement: Enzymatic method using a kit.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAmirhossein Sahebkar

Mashhad University of Medical Sciences

amir_saheb2000@yahoo.com+98 915 122 1496

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026