Evaluation the effect of curcumin-piperine supplementation on Oxidized LDL and oxidative stress index in patients with type 2 diabetic with high LDL

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230823059232N1

Enrollment

Registered

2023-12-07

Start date

2023-11-06

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

type 2 diabetic patients with high levels of low-density lipoprotein. Diabetes mellitus due to underlying condition

Interventions

Intervention 1: Intervention group: 500m/gram curcumin per day for 3 months. Intervention 2: Control group: Take placebo (500 mg of lactose) daily for 3 months.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 5 to 10 years have passed since the onset of diabetes Taking atorvastatin Glycosylated hemoglobin A1c (HbA1c) between 7 and 9% blood LDL level is more than 200 mg/dL

Exclusion criteria

Exclusion criteria: Pregnancy or breastfeeding Participating in concurrent trials Presence of malignancies r disease (alanine aminotransferase level three times the upper limit of the normal range) chronic live, renal failure chronic inflammatory diseases such as rheumatoid arthritis and acute infections thyroid disorders (such as hypothyroidism or hyperthyroidism) obsessive-compulsive disorder other types of diabetes receiving hormone or other herbal treatments hypersensitivity to curcuminoids

Design outcomes

Primary

Measure	Time frame
LDL-C. Timepoint: From the beginning of the study (before the start of the intervention) and 90 days after the start of the curcumin-piperine supplement. Method of measurement: Enzymatic method using a kit.;HDL-C. Timepoint: From the beginning of the study (before the start of the intervention) and 90 days after the start of the curcumin-piperine supplement. Method of measurement: Enzymatic method using a kit.;TG. Timepoint: From the beginning of the study (before the start of the intervention) and 90 days after the start of the curcumin-piperine supplement. Method of measurement: Enzymatic method using a kit.;Total Cholestrol. Timepoint: From the beginning of the study (before the start of the intervention) and 90 days after the start of the curcumin-piperine supplement. Method of measurement: Enzymatic method using a kit.;FBS. Timepoint: From the beginning of the study (before the start of the intervention) and 90 days after the start of the curcumin-piperine supplement. Method of measurement: Enzymatic method using a kit.;Malondialdehyde. Timepoint: From the beginning of the study (before the start of the intervention) and 90 days after the start of the curcumin-piperine supplement. Method of measurement: Enzyme method using kit.;Superoxide dismutase. Timepoint: From the beginning of the study (before the start of the intervention) and 90 days after the start of the curcumin-piperine supplement. Method of measurement: Enzyme method using kit.;Oxidized Ldl. Timepoint: From the beginning of the study (before the start of the intervention) and 90 days after the start of the curcumin-piperine supplement. Method of measurement: Enzyme method using kit.	—

Measure

Time frame

LDL-C. Timepoint: From the beginning of the study (before the start of the intervention) and 90 days after the start of the curcumin-piperine supplement. Method of measurement: Enzymatic method using a kit.;HDL-C. Timepoint: From the beginning of the study (before the start of the intervention) and 90 days after the start of the curcumin-piperine supplement. Method of measurement: Enzymatic method using a kit.;TG. Timepoint: From the beginning of the study (before the start of the intervention) and 90 days after the start of the curcumin-piperine supplement. Method of measurement: Enzymatic method using a kit.;Total Cholestrol. Timepoint: From the beginning of the study (before the start of the intervention) and 90 days after the start of the curcumin-piperine supplement. Method of measurement: Enzymatic method using a kit.;FBS. Timepoint: From the beginning of the study (before the start of the intervention) and 90 days after the start of the curcumin-piperine supplement. Method of measurement: Enzymatic method using a kit.;Malondialdehyde. Timepoint: From the beginning of the study (before the start of the intervention) and 90 days after the start of the curcumin-piperine supplement. Method of measurement: Enzyme method using kit.;Superoxide dismutase. Timepoint: From the beginning of the study (before the start of the intervention) and 90 days after the start of the curcumin-piperine supplement. Method of measurement: Enzyme method using kit.;Oxidized Ldl. Timepoint: From the beginning of the study (before the start of the intervention) and 90 days after the start of the curcumin-piperine supplement. Method of measurement: Enzyme method using kit.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactShahin Besharati

Zanjan University of Medical Sciences

shahin.besharati@zums.ac.ir+98 912 441 8600

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026