Evaluating the effectiveness of the stress ball for the management of botulinum toxin injection pain: a randomized controlled trial

Evaluating the effectiveness of stress ball for the management of botulinum toxin injection pain in volunteers receiving Botox to eliminate hyperkinetic facial wrinkles on the upper face: a randomized self-controlled trial

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230823059230N1

Enrollment

Registered

2023-09-22

Start date

2023-09-11

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Skin Wrinkle. Disorder of the skin and subcutaneous tissue, unspecified

Interventions

Intervention 1: Intervention group: participants were asked to squeeze stress balls in both hands during the BT injection (on one side of the face). Intervention 2: Control group: the group that does

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Age over 18 years. Volunteering to correct hyperkinetic facial wrinkles by intramuscular injection of Botox in the upper face, including forehead, lateral orbital, and glabellar.

Exclusion criteria

Exclusion criteria: No history of allergy to Botox

Design outcomes

Primary

Measure	Time frame
Injection pain. Timepoint: Immediately after injection. Method of measurement: Visual Analog Scale (VAS) questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Naseh

Shiraz University of Medical Sciences

naseh@sums.ac.ir+98 71 3230 5410

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026