Vitiligo. Vitiligo
Conditions
Interventions
Intervention 1: Intervention group1: Fractional Carbon dioxide laser followed by topical methotrexate. Topical eutectic mixture of local anesthetic cream will be applied over the patient’s lesions for
a resurfacing mode, pulse energy of 70–100 J/cm2, coverage and a spot density of 150 spots/cm2 (static mode). After each session topical 25mg/ml methotrexate injection, not more than 0.3 ml will be ma
Sponsors
National University of Medical Sciences
Eligibility
Sex/Gender
All
Age
10 Years to 70 Years
Inclusion criteria
Inclusion criteria: Patients willing to participate in the study Patients of age group 10 -70 years. Vitiligo involving less than or equal to 10% body surface area.
Exclusion criteria
Exclusion criteria: Patients using or have used other treatments for vitiligo in the recent past Pregnant women or lactating women Patients with segmental vitiligo Patients on immunosuppressant medications due to other diseases Patients having connective tissue diseases, epilepsy or photosensitivity disorders Patient having previous radiotherapy or phototherapy. Patients with personal or family history of melanoma and non-melanoma skin cancers Patients having contraindications to methotrexate or PUVASOL therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical improvement. Timepoint: At the end of 1st and 2nd month. Method of measurement: A blinded independent medical observer will perform clinical assessments using the following grading scale for all 30 patients: 1, 75% excellent re-pigmentation.;Patient satisfaction. Timepoint: At the end of 1st and 2nd month. Method of measurement: Patient satisfaction will also be assessed by grading scale i.e. 1. Unsatisfied, 2. Partially satisfied, 3. Completely satisfied. | — |
Countries
Pakistan
Contacts
Public ContactSakina Sadiq Malik
NUMS-Pakistan
Outcome results
None listed