Effect of N-acetylcysteine in moderate to severe traumatic brain injury

Investigating the effect of N-acetylcysteine ??on the prognosis of patients with moderate to severe traumatic brain injury who referred to the Hafte Tir Hospital from October 1402 to October 1403

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230815059150N1

Enrollment

Registered

2023-09-02

Start date

2023-09-22

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Traumatic Brain Injury. Diffuse traumatic brain injury

Interventions

Intervention 1: Intervention group: N-acetylcysteine (NAC) drug is given to patients orally with an oral dose of 3.6 grams for 4 days and then 1.8 mg for 3 days. Intervention 2: Control group: The pla

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with moderate to severe traumatic brain injury Patients over 18 years of age

Exclusion criteria

Exclusion criteria: Patients with Glasgow Coma Scale 3

Design outcomes

Primary

Measure	Time frame
The effect of NAC on the Glasgow Coma Scale (GCS) of patients with moderate to severe traumatic brain injury. Timepoint: 7 Days. Method of measurement: table of Glasgow Coma Scale.;The effect of NAC on the Glasgow Outcome Scale (GOS) of patients with moderate to severe traumatic brain injury. Timepoint: 7 Days. Method of measurement: Table of Glasgow Outcome Scale.;The effect of NAC on the Modified Rankin Scale (mRS) of patients with moderate to severe traumatic brain injury. Timepoint: 7 days. Method of measurement: Table of Modified Rankin Scale (mRS).	—

Measure

Time frame

The effect of NAC on the Glasgow Coma Scale (GCS) of patients with moderate to severe traumatic brain injury. Timepoint: 7 Days. Method of measurement: table of Glasgow Coma Scale.;The effect of NAC on the Glasgow Outcome Scale (GOS) of patients with moderate to severe traumatic brain injury. Timepoint: 7 Days. Method of measurement: Table of Glasgow Outcome Scale.;The effect of NAC on the Modified Rankin Scale (mRS) of patients with moderate to severe traumatic brain injury. Timepoint: 7 days. Method of measurement: Table of Modified Rankin Scale (mRS).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Hossein Ghazvini

Iran University of Medical Sciences

ghazvinimohammadhossein@gmail.com+98 21 2246 5720

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026